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Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.

作者信息

Schiffer D, Giordana M T, Pezzotta S, Paoletti P

出版信息

Acta Neuropathol. 1976 Jan 31;34(1):21-31. doi: 10.1007/BF00684940.

DOI:10.1007/BF00684940
PMID:175631
Abstract

The application of BCNU, CCNU and MeCCNU has been shown to greatly reduce the number of tumors induced in rats by transplacentally administered ENU and to inhibit the full development of tumor proliferation. Moreover, no neurinomas appeared after treatment with CCNU. The application of GCNU proved to be much less effective. Our statistics in the form of tables showing these findings are included and discussed.

摘要

相似文献

1
Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.
Acta Neuropathol. 1976 Jan 31;34(1):21-31. doi: 10.1007/BF00684940.
2
The effect of BCNU, CCNU and MeCCNU in the prevention of the development of tumors of the nervous system.卡莫司汀、洛莫司汀和司莫司汀在预防神经系统肿瘤发生方面的作用。
Pharmacol Res Commun. 1975 Feb;07(1):49-53. doi: 10.1016/s0031-6989(75)80029-4.
3
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Acta Neuropathol. 1978 Jan 19;41(1):27-31. doi: 10.1007/BF00689553.
4
[Experimental brain neoplasm induced transplacentally by ethylnitrosourea (ENU). (1) Sequential, localized observations and pathological studies of microtumors].[经乙基亚硝基脲（ENU）经胎盘诱导产生的实验性脑肿瘤。（1）微肿瘤的序贯性、局部观察及病理研究]
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Influence of the postnatal administration of tumor necrosis factor plus interferon-alpha 2b on the development of ethyl-nitrosourea-induced brain tumors in rats.产后给予肿瘤坏死因子加α-2b干扰素对大鼠乙基亚硝基脲诱导脑肿瘤发生发展的影响。
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Natl Cancer Inst Monogr. 1977 Dec;46:161-2.
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Influence of recombinant interleukin-2 and tumor necrosis factor-alpha on the development of ethyl nitrosourea-induced brain tumors.重组白细胞介素-2和肿瘤坏死因子-α对乙基亚硝脲诱导的脑肿瘤发生发展的影响。
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Glycosaminoglycans of brain tumors transplacentally induced by ENU in the rat.
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Quantitative aspects of transplacental tumor induction with ethylnitrosourea in rats.大鼠经胎盘用乙基亚硝基脲诱导肿瘤的定量研究。
Cancer Res. 1972 Dec;32(12):2656-60.

引用本文的文献

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Pathology of human malignant gliomas after radiation and chemotherapy.
Acta Neurochir (Wien). 1980;53(3-4):205-16. doi: 10.1007/BF02074793.
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Acta Neuropathol. 1980;49(3):199-203. doi: 10.1007/BF00707107.
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Morphological changes in anaplastic gliomas treated with radiation and chemotherapy.接受放疗和化疗的间变性胶质瘤的形态学变化。
Acta Neurochir (Wien). 1977;36(1-2):117-38. doi: 10.1007/BF01405993.

本文引用的文献

1
Some effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea upon the synthesis of protein and nucleic acids in vivo and in vitro.1,3-双（2-氯乙基）-1-亚硝基脲对体内和体外蛋白质及核酸合成的某些影响。
Cancer Res. 1965 Nov;25(10):1770-8.
2
The effects of 1,3-bis(2-chloroethyl)-1-nitrosurea on survival and cell progression in Chinese hamster cells.
Cancer Res. 1971 Feb;31(2):191-5.
3
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.实验性脑肿瘤化疗研究：1,3-双（2-氯乙基）-1-亚硝基脲、环磷酰胺、光辉霉素和甲氨蝶呤的评估
4
Cerebral tumors induced by transplacental ENU: study of the different tumoral stages, particularly of early proliferations.经胎盘注射ENU诱导的脑肿瘤：不同肿瘤阶段的研究，特别是早期增殖阶段的研究。
Acta Neuropathol. 1978 Jan 19;41(1):27-31. doi: 10.1007/BF00689553.
5
Combination chemotherapy (COMP protocol) and radiotherapy of anaplastic supratentorial gliomas.间变性幕上胶质瘤的联合化疗（COMP方案）及放疗
Acta Neurochir (Wien). 1979;51(1-2):1-13. doi: 10.1007/BF01401790.
6
Cerebral tumours induced by ENU; changes of adenylate cyclase activity in the tumour latency time.
Acta Neurochir (Wien). 1979;50(1-2):35-41. doi: 10.1007/BF01813546.
7
Glioblastoma multiforme: morphology and biology.多形性胶质母细胞瘤：形态学与生物学
Acta Neurochir (Wien). 1978;42(1-2):5-32. doi: 10.1007/BF01406628.
Cancer Res. 1970 Sep;30(9):2401-13.
4
Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and some chemically related compounds upon the progression of cultured H.Ep. no. 2 cells through the cell cycle.
Cancer Res. 1970 Jun;30(6):1817-27.
5
[Experimental cerebral tumors in rats induced with nitrosourea. Pathogenetic considerations on mixed and polymorphous gliomas].[用亚硝基脲诱导大鼠产生实验性脑肿瘤。关于混合性和多形性胶质瘤的发病机制思考]
Tumori. 1971 Sep-Oct;57(5):333-41. doi: 10.1177/030089167105700502.
6
Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics.给新生大鼠脑内或皮下注射乙基亚硝基脲诱导的神经系统肿瘤。形态学和生化特征。
J Neurosurg. 1972 Nov;37(5):580-90. doi: 10.3171/jns.1972.37.5.0580.
7
Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.一种动物脑肿瘤模型的建立及其对1,3-双(2-氯乙基)-1-亚硝基脲治疗的反应
Cancer Res. 1973 May;33(5):976-86.
8
An experimental model for selective production of neoplasms of the peripheral nervous system.一种用于选择性产生外周神经系统肿瘤的实验模型。
Acta Neuropathol. 1973 Feb 19;23(3):219-28. doi: 10.1007/BF00687877.
9
Response of cultured human glioblastomas to radiation and BCNU chemotherapy.培养的人胶质母细胞瘤对放疗和卡氮芥化疗的反应。
J Neurosurg. 1974 Sep;41(3):339-49. doi: 10.3171/jns.1974.41.3.0339.
10
Effects of cytosine arabinoside and 1,3-bis(2-chloroethyl)-1-nitrosourea on human glial tumor cells.
Cancer Res. 1972 Mar;32(3):558-64.