Zurita M, Cabrera M M, Morales C, Oya S, Vaquero J
Department of Cell Biology, Faculty of Medicine, Complutensis University, Madrid, Spain.
Neurosci Lett. 1994 Jun 20;174(2):213-6. doi: 10.1016/0304-3940(94)90024-8.
Using the experimental model of brain tumors induced by ethyl-nitrosourea (ENU), interferon-alpha 2b and human recombinant tumor necrosis factor-alpha (TNF) have been administered to Wistar rats between 100 and 130 days of life (one injection each week, by intraperitoneal route, of 100 micrograms of TNF and 10(4) IU of interferon-alpha 2b, in a total volume of 1 ml per injection). The results obtained suggest, that at this time, this association achieves a reduction in the number of so-called 'malignant schwannomas', but it does not influence the time of appearance nor the number of so-called 'malignant schwannomas', but it does not influence the time of appearance nor the number of so-called 'oligodendroglioma-like tumors'. On the basis of previous observations about cytokine modulation of these ENU-induced neoplasms, a different course of time for obtaining a postnatal biomodulation of both type of tumors is suggested.
利用乙基亚硝基脲（ENU）诱导脑肿瘤的实验模型，在100至130日龄的Wistar大鼠中给予α-干扰素2b和人重组肿瘤坏死因子-α（TNF）（每周腹腔注射一次，每次注射100微克TNF和10⁴国际单位的α-干扰素2b，每次注射总体积为1毫升）。所得结果表明，此时这种联合用药可使所谓的“恶性神经鞘瘤”数量减少，但对所谓的“少突胶质细胞瘤样肿瘤”的出现时间和数量并无影响。基于先前关于这些ENU诱导肿瘤的细胞因子调节的观察结果，提出了获得两种肿瘤产后生物调节的不同时间进程。
