Vaquero J, Zurita M, Oya S
Neurosciences Research Unit of the Mapfre-Medicine Foundation, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Cancer Lett. 1998 Jan 16;123(1):95-8. doi: 10.1016/s0304-3835(97)00420-5.
Immunological suppression of the immune-cell system by means of cyclosporin-A was performed at a stage corresponding to microtumor development in the ethyl-nitrosourea (ENU) model of neurocarcinogenesis. The results that we have obtained suggest that this immunological manipulation is related to the appearance of extraneural undifferentiated tumors, suggesting that the immune-cell system is effective in immunocompetent rodents for providing extraneural ENU carcinogenesis.
在神经致癌作用的乙基亚硝基脲（ENU）模型中，于对应微肿瘤发展的阶段，通过环孢菌素A对免疫细胞系统进行免疫抑制。我们所获得的结果表明，这种免疫操作与神经外未分化肿瘤的出现有关，这表明免疫细胞系统在具有免疫活性的啮齿动物中对神经外ENU致癌作用具有抑制效果。
