Li Chen, Gloer James B, Wicklow Donald T
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
J Nat Prod. 2003 Sep;66(9):1232-5. doi: 10.1021/np030192m.
Three new 3-substituted indole diterpenoids (thiersindoles A-C; 1-3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A-C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.
从一种新的青霉属物种（蒂尔斯青霉）的有机提取物中分离出了三种新的3-取代吲哚二萜类化合物（蒂尔斯吲哚A - C；1 - 3）。通过核磁共振数据的分析以及莫舍尔方法的应用确定了它们的结构，包括绝对立体化学结构。蒂尔斯吲哚A - C在生源上与黄曲霉素相关，尽管化合物1和2中的[6,6,5]三环二萜骨架在该类已知成员中前所未见。
