从真菌 - 衍生的 sp. PQJ-1 中分离得到的细胞毒性吲哚二萜。
Cytotoxic Indole Diterpenoids from a -Derived Fungus sp. PQJ-1.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
出版信息
Molecules. 2023 Oct 10;28(20):7003. doi: 10.3390/molecules28207003.
Two new indole diterpene derivatives, 5-hydroxy--aflatrem () and 14-hydroxy--aflatrem (), along with one known analogue, 14-(,-dimethl--valyloxy)paspalinine (), were isolated from the fermentation broth of the fungus sp. PQJ-1 derived from . The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. All the compounds (-) were evaluated for their cytotoxicity against A549, Hela, Hep G2, and MCF-7 cell lines. Compounds and exhibited selective inhibition against Hela cells. Further studies showed that significantly induced apoptosis and suppressed migration and invasion in Hela cells. Moreover, could up-regulate pro-apoptotic genes BAX and Caspase-3 and down-regulate anti-apoptotic genes Bcl-xL and XIXP.
从采自 的真菌 sp. PQJ-1 的发酵液中分离得到了两个新的吲哚二萜衍生物，5-羟基--黄曲霉毒素 () 和 14-羟基--黄曲霉毒素 ()，以及一个已知类似物 14-(-，-二甲- -缬氨酰氧基)巴卡丁 (). 新化合物的结构通过光谱数据和 ECD 光谱分析阐明。所有化合物 (-) 都对 A549、Hela、Hep G2 和 MCF-7 细胞系进行了细胞毒性评估。化合物 和 对 Hela 细胞表现出选择性抑制作用。进一步的研究表明， 能显著诱导 Hela 细胞凋亡，并抑制其迁移和侵袭。此外， 可上调促凋亡基因 BAX 和 Caspase-3，下调抗凋亡基因 Bcl-xL 和 XIXP。
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