Nilsson S, Berglund I, Erikson U, Johansson J, Walldius G
Department of Oncology, Radiology and Clinical Immunology, University Hospital, SE-751 85 Uppsala, Sweden.
Acta Radiol. 2003 Sep;44(5):489-93. doi: 10.1080/j.1600-0455.2003.00101.x.
To determine which phase of the heart cycle would yield the highest reproducibility in measuring atherosclerosis-related variables such as arterial lumen volume and edge roughness.
35 patients with hypercholesterolemia underwent select- ive femoral angiography, repeated four times at 10-min intervals. The angiographies were performed with ECG-gated exposures. In angiographies 1 and 2 the delay from R-wave maximum to each exposure was 0.1 s, in angiographies 3 and 4 the delay was 0.1, 0.3, 0.5 or 0.7 s or the exposures were performed 1/s without ECG gating. Arterial lumen volume and edge roughness were measured in a 20-cm segment of the superficial femoral artery using a computer-based densitometric method. Measurement reproducibility was determined by comparing angiographies 1-2 and angiographies 3-4.
When measuring arterial lumen volume and edge roughness of a 20-cm segment of the femoral artery, reproducibility was not dependent on ECG gating. In measuring single arterial diameters and cross-sectional areas, the reproducibility was better when exposures were made 0.1 s after the R-wave maximum than when using other settings of the ECG gating device or without ECG gating.
The influence of pulsatile flow upon quantitative measurement in femoral angiograms seems to be the smallest possible in early systole, as can be demonstrated when measuring single diameters and cross-sectional areas. In variables based on integration over longer segments, measurement reproducibility seems to be independent of phase.
确定心动周期的哪个阶段在测量动脉粥样硬化相关变量（如动脉管腔容积和边缘粗糙度）时具有最高的可重复性。
35例高胆固醇血症患者接受选择性股动脉血管造影，每隔10分钟重复进行4次。血管造影采用心电图门控曝光。在第1次和第2次血管造影中，从R波峰值到每次曝光的延迟为0.1秒，在第3次和第4次血管造影中，延迟为0.1、0.3、0.5或0.7秒，或者在没有心电图门控的情况下以1次/秒的频率进行曝光。使用基于计算机的密度测定法在股浅动脉20厘米段测量动脉管腔容积和边缘粗糙度。通过比较第1 - 2次血管造影和第3 - 4次血管造影来确定测量的可重复性。
在测量股动脉20厘米段的动脉管腔容积和边缘粗糙度时，可重复性不依赖于心电图门控。在测量单个动脉直径和横截面积时，在R波峰值后0.1秒进行曝光时的可重复性优于使用心电图门控设备的其他设置或无心电图门控时的情况。
在测量单个直径和横截面积时可以证明，搏动血流对股动脉血管造影定量测量的影响在收缩早期似乎最小。在基于较长节段积分的变量中，测量的可重复性似乎与相位无关。
