Al-Daghri N, Al-Rubean K, Bartlett W A, Al-Attas O, Jones A F, Kumar S
Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.
Diabet Med. 2003 Oct;20(10):832-7. doi: 10.1046/j.1464-5491.2003.01044.x.
To compare plasma leptin in Saudi subjects with Type 2 diabetes and coronary heart disease (CHD) with non-diabetic control subjects and to examine the relationship of plasma leptin to other CHD risk factors.
Serum leptin concentrations were measured in 144 Saudi men. Subjects studied included 59 with Type 2 diabetes mellitus [BMI 27.5 (3.7) kg/m2 mean (sd)], 34 with coronary heart disease [BMI 29.6 (1.8) kg/m2], and 51 non-diabetic controls [BMI 28.0 (3.5) kg/m2]. There was no significant difference in BMI between the groups. Fasting serum leptin, lipids, insulin, apolipoproteins and glucose were measured. BMI, blood pressure; smoking habit and age were also recorded. Insulin resistance was assessed using the HOMA model.
Leptin concentrations were significantly higher in diabetic and CHD patients than in controls (P = 0.024 and 0.016, respectively). Multiple regression analysis showed that body weight (P < 0.0006), serum triglyceride concentration (P = 0.046) and systolic blood pressure (P = 0.013) were all significantly related to the logarithm of the serum leptin concentration (R2 = 0.549) in CHD patients. A subgroup analysis, comparing those patients who had the metabolic syndrome, as defined by WHO, with controls, showed higher serum leptin in those with metabolic syndrome (P = 0.05).
Serum leptin is increased in Saudi subjects with diabetes mellitus, metabolic syndrome and CHD. Leptin may be a marker of risk of CHD, at least in men, and contribute to the CHD risk profile in subjects with insulin resistance. Further studies are needed to evaluate this relationship prospectively.
比较沙特2型糖尿病和冠心病（CHD）患者与非糖尿病对照者的血浆瘦素水平，并研究血浆瘦素与其他冠心病危险因素的关系。
测定了144名沙特男性的血清瘦素浓度。研究对象包括59名2型糖尿病患者[体重指数（BMI）为27.5（3.7）kg/m²，均值（标准差）]、34名冠心病患者[BMI为29.6（1.8）kg/m²]和51名非糖尿病对照者[BMI为28.0（3.5）kg/m²]。各组间BMI无显著差异。测定了空腹血清瘦素、血脂、胰岛素、载脂蛋白和血糖。还记录了BMI、血压、吸烟习惯和年龄。采用稳态模型评估胰岛素抵抗。
糖尿病患者和冠心病患者的瘦素浓度显著高于对照组（分别为P = 0.024和0.016）。多元回归分析显示，冠心病患者的体重（P < 0.0006）、血清甘油三酯浓度（P = 0.046）和收缩压（P = 0.013）均与血清瘦素浓度的对数显著相关（R² = 0.549）。一项亚组分析比较了符合世界卫生组织定义的代谢综合征患者与对照组，结果显示代谢综合征患者的血清瘦素水平较高（P = 0.05）。
沙特糖尿病、代谢综合征和冠心病患者的血清瘦素水平升高。瘦素可能是冠心病风险的一个标志物，至少在男性中如此，并在胰岛素抵抗患者的冠心病风险谱中起作用。需要进一步研究前瞻性地评估这种关系。
