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本文引用的文献

1
Drugs and falls in later life.老年期的药物与跌倒
Lancet. 2003 Feb 8;361(9356):448. doi: 10.1016/S0140-6736(03)12502-0.
2
Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study.老年女性心血管疾病、危险因素及其控制情况的地域差异:英国女性心脏与健康研究
J Epidemiol Community Health. 2003 Feb;57(2):134-40. doi: 10.1136/jech.57.2.134.
3
Clinical practice. Preventing falls in elderly persons.临床实践。预防老年人跌倒。
N Engl J Med. 2003 Jan 2;348(1):42-9. doi: 10.1056/NEJMcp020719.
4
Socioeconomic position in childhood and adulthood and insulin resistance: cross sectional survey using data from British women's heart and health study.儿童期和成年期的社会经济地位与胰岛素抵抗:利用英国女性心脏与健康研究数据进行的横断面调查
BMJ. 2002 Oct 12;325(7368):805. doi: 10.1136/bmj.325.7368.805.
5
Central nervous system-active medications and risk for falls in older women.中枢神经系统活性药物与老年女性跌倒风险
J Am Geriatr Soc. 2002 Oct;50(10):1629-37. doi: 10.1046/j.1532-5415.2002.50453.x.
6
The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study.成人身高各组成部分与2型糖尿病及胰岛素抵抗之间的关联:英国女性心脏与健康研究
Diabetologia. 2002 Aug;45(8):1097-106. doi: 10.1007/s00125-002-0887-5. Epub 2002 Jun 28.
7
Later management of documented ischaemic heart disease: secondary prevention and rehabilitation.
Br Med Bull. 2001;59:113-33. doi: 10.1093/bmb/59.1.113.
8
Management of postural hypotension.体位性低血压的管理。
Curr Hypertens Rep. 2000 Oct;2(5):457-62. doi: 10.1007/s11906-000-0028-9.
9
Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial.精神药物戒断与家庭锻炼计划预防跌倒:一项随机对照试验。
J Am Geriatr Soc. 1999 Jul;47(7):850-3. doi: 10.1111/j.1532-5415.1999.tb03843.x.
10
Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs.老年人用药与跌倒:系统评价和荟萃分析:I. 精神药物
J Am Geriatr Soc. 1999 Jan;47(1):30-9. doi: 10.1111/j.1532-5415.1999.tb01898.x.

老年女性跌倒与慢性病及药物使用之间的关联:横断面研究。

Association between falls in elderly women and chronic diseases and drug use: cross sectional study.

作者信息

Lawlor Debbie A, Patel Rita, Ebrahim Shah

机构信息

Department of Social Medicine, University of Bristol, Bristol BS8 2PR.

出版信息

BMJ. 2003 Sep 27;327(7417):712-7. doi: 10.1136/bmj.327.7417.712.

DOI:10.1136/bmj.327.7417.712
PMID:14512478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC200802/
Abstract

OBJECTIVE

To assess the associations between having had a fall and chronic diseases and drug use in elderly women.

DESIGN

Cross sectional survey, using data from the British women's heart and health study.

SETTING

General practices in 23 towns in Great Britain.

PARTICIPANTS

4050 women aged 60-79 years.

MAIN OUTCOME MEASURE

Whether women had had falls in the previous 12 months.

RESULTS

The prevalence of falling increased with increasing numbers of simultaneously occurring chronic diseases. However, no such relation with falling was found in the fully adjusted data for the number of drugs used. Circulatory disease, chronic obstructive pulmonary disease, depression, and arthritis were all associated with an increased odds of falling. The fully adjusted, population attributable risk of falling associated with having at least one chronic disease was 32.2% (95% confidence interval 19.6% to 42.8%). Only two classes of drugs (hypnotics and anxiolytics, and antidepressants) were independently associated with an increased odds of falling. Each class was associated with an increase of about 50% in the odds of falling, and each had a population attributable risk of < 5%.

CONCLUSION

Chronic diseases and multiple pathology are more important predictors of falling than polypharmacy.

摘要

目的

评估老年女性跌倒与慢性病及药物使用之间的关联。

设计

横断面调查,使用英国女性心脏与健康研究的数据。

地点

英国23个城镇的全科医疗诊所。

参与者

4050名年龄在60 - 79岁的女性。

主要观察指标

女性在过去12个月内是否跌倒。

结果

跌倒的患病率随着同时发生的慢性病数量增加而上升。然而,在对用药数量进行完全调整的数据中未发现与跌倒有此类关联。循环系统疾病、慢性阻塞性肺疾病、抑郁症和关节炎均与跌倒几率增加相关。至少有一种慢性病与跌倒相关的完全调整后的人群归因风险为32.2%(95%置信区间为19.6%至42.8%)。只有两类药物(催眠药和抗焦虑药以及抗抑郁药)与跌倒几率增加独立相关。每类药物与跌倒几率增加约50%相关,且每类药物的人群归因风险均<5%。

结论

慢性病和多种病理状况比多重用药更能预测跌倒。