Gautschi O, Berger C, Gubler J, Laube I
Department of Internal Medicine, Triemli Hospital, Zürich, Switzerland.
Respiration. 2003 Jul-Aug;70(4):419-22. doi: 10.1159/000072908.
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus with worldwide distribution. Primary infection with EBV occurs early in life and typically presents as infectious mononucleosis. The usual course of the disease is benign and most patients recover uneventfully. Severe infections are reported particularly in immunocompromised patients. Mild, asymptomatic pneumonitis is reported in about 5-10% of cases of infectious mononucleosis, but severe pneumonitis with hypoxemia is very rare in immunocompetent individuals. We report a young female adolescent in whom an acute EBV infection led to severe bilateral pneumonitis, a systemic inflammatory response and intracerebral bleeding. The clinical course and results of quantitative viral DNA determinations in plasma are presented.
爱泼斯坦-巴尔病毒（EBV）是一种广泛分布于全球的人类疱疹病毒。EBV的初次感染发生在生命早期，通常表现为传染性单核细胞增多症。该病的通常病程是良性的，大多数患者可顺利康复。严重感染尤其在免疫功能低下的患者中报道。据报道，约5%-10%的传染性单核细胞增多症病例会出现轻度、无症状肺炎，但免疫功能正常的个体中出现伴有低氧血症的严重肺炎非常罕见。我们报告了一名年轻女性青少年，其急性EBV感染导致严重双侧肺炎、全身炎症反应和脑出血。本文介绍了其临床病程及血浆中病毒DNA定量测定结果。
