Ascenção Bianca Branco, Gonçalves Ana Catarina, Luís Nuno, Sá Joana, Brito Ana Paula, Poças José Manuel
Centro Hospitalar de Setúbal, Setubal, Portugal.
J Neurovirol. 2016 Oct;22(5):695-698. doi: 10.1007/s13365-016-0430-y. Epub 2016 Mar 4.
Neurologic complications related to Epstein-Barr virus (EBV) in immunocompetent adults are rare and most commonly self-limited. However, severe cases have been previously reported in the literature. We describe a case of meningoencephalitis with frontal bilateral hemorrhage in a non-immunocompromised adult following an EBV infection of the central nervous system confirmed by the presence of EBV-DNA in the cerebrospinal fluid. During the patient's hospital stay, there was a favorable clinical and radiologic evolution and the patient was discharged asymptomatic. To our knowledge, this is the fourth case of hemorrhagic meningoencephalitis related to EBV and the first one in an immunocompetent patient with a favorable outcome.
在免疫功能正常的成年人中,与爱泼斯坦-巴尔病毒(EBV)相关的神经系统并发症很少见,且大多为自限性。然而,此前文献中已有严重病例的报道。我们描述了一例非免疫功能低下的成年人在中枢神经系统感染EBV后发生双侧额叶出血性脑膜脑炎的病例,脑脊液中EBV-DNA的存在证实了这一感染。在患者住院期间,临床和影像学表现均有良好进展,患者出院时无症状。据我们所知,这是第四例与EBV相关的出血性脑膜脑炎病例,也是第一例在免疫功能正常的患者中取得良好预后的病例。