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EI-1941-1 and -2, novel interleukin-1 beta converting enzyme inhibitors Produced by Farrowia sp. E-1941. II. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.

作者信息

Koizumi Fumito, Ishiguro Hiroki, Ando Katsuhiko, Kondo Hidemasa, Yoshida Mayumi, Matsuda Yuzuru, Nakanishi Satoshi

机构信息

Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida-shi, Tokyo 194-8533, Japan.

出版信息

J Antibiot (Tokyo). 2003 Jul;56(7):603-9. doi: 10.7164/antibiotics.56.603.

DOI:10.7164/antibiotics.56.603
PMID:14513902
Abstract

EI-1941-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Farrowia sp. E-1941. EI-1941-1 and -2 selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006 microM, respectively. Taxonomy and fermentation of the producing strain and isolation, physico-chemical properties, structure elucidation, and biological properties of EI-1941-1 and -2 are described.

摘要

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