• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

EI-2128-1，一种由青霉菌E-2128产生的新型白细胞介素-1β转化酶抑制剂。

EI-2128-1, a novel interleukin-1beta converting enzyme inhibitor produced by Penicillium sp. E-2128.

作者信息

Koizumi Fumito, Agatsuma Tsutomu, Ando Katsuhiko, Kondo Hidemasa, Saitoh Yutaka, Matsuda Yuzuru, Nakanishi Satoshi

机构信息

Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida-shi, Tokyo 194-8533, Japan.

出版信息

J Antibiot (Tokyo). 2003 Nov;56(11):891-8. doi: 10.7164/antibiotics.56.891.

DOI:10.7164/antibiotics.56.891
PMID:14763553
Abstract

EI-2128-1, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Penicillium sp. E-2128. EI-2128-1 selectively inhibited human recombinant ICE activity with IC50 value of 0.59 microM, without inhibiting elastase and cathepsin B. EI-2128-1 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with IC50 value of 0.28 microM.

摘要

EI-2128-1是一种新型白细胞介素-1β转化酶（ICE）抑制剂，从青霉菌E-2128的培养液中分离得到。EI-2128-1选择性抑制人重组ICE活性，IC50值为0.59微摩尔，而不抑制弹性蛋白酶和组织蛋白酶B。EI-2128-1还抑制脂多糖诱导的THP-1细胞分泌成熟白细胞介素-1β，IC50值为0.28微摩尔。

相似文献

1
EI-2128-1, a novel interleukin-1beta converting enzyme inhibitor produced by Penicillium sp. E-2128.EI-2128-1，一种由青霉菌E-2128产生的新型白细胞介素-1β转化酶抑制剂。
J Antibiot (Tokyo). 2003 Nov;56(11):891-8. doi: 10.7164/antibiotics.56.891.
2
EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.
J Antibiot (Tokyo). 2003 Dec;56(12):985-92. doi: 10.7164/antibiotics.56.985.
3
EI-1941-1 and -2, novel interleukin-1beta converting enzyme inhibitors produced by Farrowia sp. E-1941. I. Biochemical characterization of EI-1941-1 and -2.
J Antibiot (Tokyo). 2003 May;56(5):464-9. doi: 10.7164/antibiotics.56.464.
4
EI-1941-1 and -2, novel interleukin-1 beta converting enzyme inhibitors Produced by Farrowia sp. E-1941. II. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.
J Antibiot (Tokyo). 2003 Jul;56(7):603-9. doi: 10.7164/antibiotics.56.603.
5
EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. III. Biochemical properties of EI-1511-3, -5 and EI-1625-2.
J Antibiot (Tokyo). 1996 Nov;49(11):1085-90. doi: 10.7164/antibiotics.49.1085.
6
EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. I. Taxonomy of producing strain, fermentation and isolation.
J Antibiot (Tokyo). 1996 Nov;49(11):1073-8. doi: 10.7164/antibiotics.49.1073.
7
EI-1507-1 and -2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1507.EI - 1507 - 1和 - 2，由链霉菌属E - 1507产生的新型白细胞介素 - 1β转化酶抑制剂。
J Antibiot (Tokyo). 1996 Apr;49(4):333-9. doi: 10.7164/antibiotics.49.333.
8
Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.头孢菌素H和I，两种源自海洋真菌青霉菌的新型内酯
Arch Pharm Res. 2007 Jul;30(7):812-5. doi: 10.1007/BF02978829.
9
Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity.曲霉酸，一种由短柄曲霉产生的新型代谢产物，可抑制肿瘤细胞乙酰肝素酶：产生菌株的分类学、发酵、分离、结构解析及生物活性
J Antibiot (Tokyo). 1995 May;48(5):357-62. doi: 10.7164/antibiotics.48.357.
10
Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.白细胞介素-1β转化酶抑制剂EI-1941-1、-2和-3的对映选择性和非对映选择性全合成及其衍生物的生物学性质
J Org Chem. 2005 Nov 25;70(24):9905-15. doi: 10.1021/jo0516436.

引用本文的文献

1
Total synthesis of (-)-penicimutanin a and related congeners.（-）-青霉突变素a及相关同系物的全合成。
Chem Sci. 2019 Nov 20;11(3):656-660. doi: 10.1039/c9sc05252f.
2
Small Molecule Active Site Directed Tools for Studying Human Caspases.用于研究人类半胱天冬酶的小分子活性位点导向工具
Chem Rev. 2015 Nov 25;115(22):12546-629. doi: 10.1021/acs.chemrev.5b00434. Epub 2015 Nov 9.
3
A practical strategy to discover new antitumor compounds by activating silent metabolite production in fungi by diethyl sulphate mutagenesis.一种通过硫酸二乙酯诱变激活真菌中沉默代谢产物生成来发现新型抗肿瘤化合物的实用策略。
Mar Drugs. 2014 Mar 27;12(4):1788-814. doi: 10.3390/md12041788.