Nishioka Motomu, Nishimura Takuro, Ookubo Akira, Taya Masahito
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Japan.
Biotechnol Lett. 2003 Aug;25(15):1263-6. doi: 10.1023/a:1025031111800.
Silver-loaded zirconium phosphate (AgZ) was combined with hydroxyapatite (HA) to prepare an antibacterial composite (AgZ/HA) with improved activity in the presence of Cl-. When Escherichia coli cells were deactivated in 154 mM NaCl, the bacterial survival ratio at 90 min for AgZ/HA was 3.9 x 10(-4) compared to 1.2 x 10(-1) for AgZ itself. Because the bactericidal activity of AgZ/HA decreased with increasing phosphate ion up to 10 mM, cell adsorption onto the combined HA moiety probably compensated for the Cl- -induced deterioration in the activity of the silver-based bactericide.
将载银磷酸锆（AgZ）与羟基磷灰石（HA）结合，制备了一种在Cl-存在下活性增强的抗菌复合材料（AgZ/HA）。当在154 mM NaCl中使大肠杆菌细胞失活时，AgZ/HA在90分钟时的细菌存活率为3.9×10-4，而AgZ本身为1.2×10-1。由于高达10 mM的磷酸根离子会使AgZ/HA的杀菌活性降低，因此细胞在复合HA部分上的吸附可能补偿了Cl-诱导的银基杀菌剂活性的降低。
