Tunbäck Petra, Bergström Tomas, Andersson Ann-Sofi, Nordin Per, Krantz Ingela, Löwhagen Gun-Britt
Department of Dermatovenereology, Göteborg University, Göteborg, Sweden.
Scand J Infect Dis. 2003;35(8):498-502. doi: 10.1080/00365540310013018.
The changing spectrum of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) infections makes it important to define the seroepidemiology of HSV. The object of this study was to determine the prevalence of HSV-1 and HSV-2 immunoglobulin G antibodies in a young Swedish population by investigating 2106 serum samples from people aged 0-19 y. Sera were tested in HSV type-specific enzyme-linked immunosorbent assays using glycoprotein G-1 (gG-1) and glycoprotein G-2 (gG-2) as antigens. The overall seroprevalence was 31% (95% CI 29-33) for HSV-1 and 0.5% (95% CI 0.2-0.9) for HSV-2. The HSV-1 seroprevalence was higher with increasing age, and significantly higher in the age cohort 15-19 y compared with 1-4-y-olds (37% vs 24%). The HSV-1 infection seemed to be acquired early in life. In the age cohort 1-2 y, the prevalence was over 20%, presumably reflecting an established viral infection. In adolescence the HSV-1 seroprevalence may reflect both oral and sexual transmission. The seroprevalence in the oldest age cohort did not differ significantly from that seen in a Swedish study in which sera were sampled from young girls in the 1970s.
单纯疱疹病毒1型（HSV-1）和单纯疱疹病毒2型（HSV-2）感染谱的变化使得明确HSV的血清流行病学变得很重要。本研究的目的是通过调查2106份0至19岁人群的血清样本，确定瑞典年轻人群中HSV-1和HSV-2免疫球蛋白G抗体的流行情况。血清在HSV型特异性酶联免疫吸附试验中进行检测，使用糖蛋白G-1（gG-1）和糖蛋白G-2（gG-2）作为抗原。HSV-1的总体血清阳性率为31%（95%CI 29-33），HSV-2为0.5%（95%CI 0.2-0.9）。HSV-1血清阳性率随年龄增长而升高，15至19岁年龄组显著高于1至4岁年龄组（37%对24%）。HSV-1感染似乎在生命早期获得。在1至2岁年龄组，患病率超过20%，可能反映了已确立的病毒感染。在青春期，HSV-1血清阳性率可能反映了口腔和性传播。最年长年龄组的血清阳性率与一项瑞典研究中从20世纪70年代年轻女孩中采集血清的研究结果无显著差异。
