Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany.
Euro Surveill. 2011 Nov 3;16(44):20005.
The prevalence of herpes simplex virus (HSV) type-specific IgG was determined in sera taken in 1999 to 2006 from 1,100 children aged 0–18 years, 800 blood donors and 200 pregnant women in Thuringia, Germany, using tests based on the HSV glycoproteins (g) gG. By the age of 10–12 years, HSV-1 IgG prevalence reached 57.3%, rising to 69.3% by the age of 16–18 years and to 78.0% by the age of 28–30 years. Between 2.7% and 4.7% of the children aged up to 15 years had HSV-2 antibodies, increasing to 7.3% at the age of 16–18 years and to 13.6% among adults. The prevalence of HSV-1 antibodies among girls was significantly lower than among boys and a significantly higher prevalence of HSV-2 IgG in women than in men was detected. The reduced incidence of HSV-1 infections during childhood, especially in girls, has to be followed up since a higher number of primary HSV-2 infections may result. Between 2.7% and 4.7% of all children tested seemed to acquire HSV-2 by intrauterine or neonatal infection. We also compared the use of gG-1 with gC-1: the agreement of 97.2% between the two ELISAs suggests that gG-1 and gC-1 can be considered equivalent antigenic targets.
对德国图林根州 1999 年至 2006 年间采集的 1100 名 0-18 岁儿童、800 名献血者和 200 名孕妇的血清进行了单纯疱疹病毒（HSV）型特异性 IgG 的检测，检测方法基于 HSV 糖蛋白（g）gG。到 10-12 岁时，HSV-1 IgG 流行率达到 57.3%，到 16-18 岁时上升至 69.3%，到 28-30 岁时上升至 78.0%。在 15 岁以下的儿童中，有 2.7%-4.7%有 HSV-2 抗体，在 16-18 岁时上升至 7.3%，在成年人中上升至 13.6%。女孩的 HSV-1 抗体流行率明显低于男孩，并且发现女性的 HSV-2 IgG 流行率明显高于男性。儿童时期 HSV-1 感染率的降低，尤其是在女孩中，需要进一步关注，因为可能会导致更多的原发性 HSV-2 感染。在接受检测的所有儿童中，有 2.7%-4.7%似乎通过宫内或新生儿感染获得了 HSV-2。我们还比较了 gG-1 和 gC-1 的使用：两种 ELISA 的一致性为 97.2%，表明 gG-1 和 gC-1 可以被视为等效的抗原靶标。
