Wang L H, Strittmatter S M
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
J Neurosci. 1996 Oct 1;16(19):6197-207. doi: 10.1523/JNEUROSCI.16-19-06197.1996.
Members of the collapsin/semaphorin family play an important role in creating the complex pattern of neuronal connectivity. Inhibition of growth cone motility by chick collapsin is mediated by the intraneuronal protein CRMP-62. We have now isolated four rat sequences that are highly related to chick CRMP-62. All four genes are expressed exclusively in the nervous system and primarily during development. Rat CRMP-2/TOAD-64 is most closely related to chick CRMP-62 and is the most widely expressed CRMP within the nervous system. Rat CRMP-1 and CRMP-4/rUlip are expressed during discrete periods of neuronal development and are not found in the adult nervous system. Rat CRMP-3 has a distinct distribution, being expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. The differential expression of these genes suggests that CRMPs may transduce signals from different semaphorins and that semaphorins may regulate the plasticity of the adult nervous system.
塌陷蛋白/信号素家族成员在构建复杂的神经元连接模式中发挥着重要作用。鸡源塌陷蛋白对生长锥运动的抑制作用是由神经元内蛋白CRMP - 62介导的。我们现已分离出四个与鸡源CRMP - 62高度相关的大鼠序列。所有这四个基因仅在神经系统中表达，且主要在发育过程中表达。大鼠CRMP - 2/TOAD - 64与鸡源CRMP - 62关系最为密切，是神经系统中表达最为广泛的CRMP。大鼠CRMP - 1和CRMP - 4/rUlip在神经元发育的特定时期表达，在成体神经系统中未发现。大鼠CRMP - 3具有独特的分布，在发育中的脊髓中短暂表达，在出生后的小脑中选择性表达。这些基因的差异表达表明，CRMPs可能转导来自不同信号素的信号，并且信号素可能调节成体神经系统的可塑性。
