大鼠CRMP基因家族在神经系统中存在差异表达。
A family of rat CRMP genes is differentially expressed in the nervous system.
作者信息
Wang L H, Strittmatter S M
机构信息
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
J Neurosci. 1996 Oct 1;16(19):6197-207. doi: 10.1523/JNEUROSCI.16-19-06197.1996.
Abstract
Members of the collapsin/semaphorin family play an important role in creating the complex pattern of neuronal connectivity. Inhibition of growth cone motility by chick collapsin is mediated by the intraneuronal protein CRMP-62. We have now isolated four rat sequences that are highly related to chick CRMP-62. All four genes are expressed exclusively in the nervous system and primarily during development. Rat CRMP-2/TOAD-64 is most closely related to chick CRMP-62 and is the most widely expressed CRMP within the nervous system. Rat CRMP-1 and CRMP-4/rUlip are expressed during discrete periods of neuronal development and are not found in the adult nervous system. Rat CRMP-3 has a distinct distribution, being expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. The differential expression of these genes suggests that CRMPs may transduce signals from different semaphorins and that semaphorins may regulate the plasticity of the adult nervous system.
摘要
塌陷蛋白/信号素家族成员在构建复杂的神经元连接模式中发挥着重要作用。鸡源塌陷蛋白对生长锥运动的抑制作用是由神经元内蛋白CRMP - 62介导的。我们现已分离出四个与鸡源CRMP - 62高度相关的大鼠序列。所有这四个基因仅在神经系统中表达，且主要在发育过程中表达。大鼠CRMP - 2/TOAD - 64与鸡源CRMP - 62关系最为密切，是神经系统中表达最为广泛的CRMP。大鼠CRMP - 1和CRMP - 4/rUlip在神经元发育的特定时期表达，在成体神经系统中未发现。大鼠CRMP - 3具有独特的分布，在发育中的脊髓中短暂表达，在出生后的小脑中选择性表达。这些基因的差异表达表明，CRMPs可能转导来自不同信号素的信号，并且信号素可能调节成体神经系统的可塑性。
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本文引用的文献
1
Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product.轴突导向相关的unc-33基因产物的假定哺乳动物同源物——Unc-33样磷蛋白（Ulip）的鉴定与分子特征分析
J Neurosci. 1996 Jan 15;16(2):688-701. doi: 10.1523/JNEUROSCI.16-02-00688.1996.
2
Mediation by G proteins of signals that cause collapse of growth cones.G蛋白介导导致生长锥塌陷的信号。
Science. 1993 Jan 1;259(5091):77-9. doi: 10.1126/science.8418498.
3
Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.坍塌蛋白：一种存在于大脑中的蛋白质，可诱导神经元生长锥的坍塌和麻痹。
Cell. 1993 Oct 22;75(2):217-27. doi: 10.1016/0092-8674(93)80064-l.
4
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.信号素基因编码一类跨膜和分泌型生长锥导向分子。
Cell. 1993 Dec 31;75(7):1389-99. doi: 10.1016/0092-8674(93)90625-z.
5
Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts.通过与组织切片和整装片进行原位杂交来检测信使核糖核酸。
Methods Enzymol. 1993;225:361-73. doi: 10.1016/0076-6879(93)25025-w.
6
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.秀丽隐杆线虫轴突伸长所需的unc-51基因编码一种新型丝氨酸/苏氨酸激酶。
Genes Dev. 1994 Oct 15;8(20):2389-400. doi: 10.1101/gad.8.20.2389.
7
Semaphorin II can function as a selective inhibitor of specific synaptic arborizations.信号素II可作为特定突触分支的选择性抑制剂发挥作用。
Cell. 1995 May 19;81(4):631-9. doi: 10.1016/0092-8674(95)90084-5.
8
Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord.信号素III可作为一种选择性化学排斥剂，用于构建脊髓中的感觉投射模式。
Neuron. 1995 May;14(5):949-59. doi: 10.1016/0896-6273(95)90333-x.
9
Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.小鼠信号素D/坍塌蛋白是一个多样基因家族的成员，可产生抑制轴突延伸的结构域。
Neuron. 1995 May;14(5):941-8. doi: 10.1016/0896-6273(95)90332-1.
10
Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33.由一种与UNC-33相关的细胞内蛋白质介导的萎缩蛋白诱导的生长锥塌陷。
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