肿瘤坏死因子-α转换酶的结构与功能
Structure and functions of tumor necrosis factor-alpha converting enzyme.
作者信息
Mezyk Renata, Bzowska Monika, Bereta Joanna
机构信息
Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Kraków, Poland.
出版信息
Acta Biochim Pol. 2003;50(3):625-45.
PMID:14515145
Abstract
Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.
摘要
肿瘤坏死因子-α转化酶（TACE）是首个被描述且特征最为明确的分泌酶。在本综述中，TACE的结构及其可能的作用被总结。TACE活性的底物特异性、调节以及不同分泌酶的冗余性和可能的协同作用也进行了讨论。
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