Zhang D F, Zhou Y S, Jia X P
Institute of Viral Hepatitis, Chongquing University of Medical Sciences.
Chin Med J (Engl). 1992 Jul;105(7):539-43.
Anti-HCV assay with ORTHO kits was done in 100 blood donors and recipients and 374 cases of viral hepatitis, including 65 cases of fulminant, subacute and chronic hepatic failure. None of the 100 blood donors and recipients showed positive anti-HCV response. Anti-HCV was positive in 7.6% of the patients with chronic persistent hepatitis, 9.7% of the patients with chronic active hepatitis and 23.1% of the patients with liver cirrhosis. High prevalence of anti-HCV was observed in subacute hepatic failure (60.8%) and chronic hepatic failure (53.9%). Fifty-two (83.9%) of 62 anti-HCV positive cases were infected concurrently with HBV. The incidence of HBV replicating marker in patients with HCV or co-infected with HBV was lower than that of those with HBV alone. It is suggested that HCV might inhibit the replication of hepatitis B virus. The mortality rate of patients with anti-HCV positive hepatic failure was higher than that of those with HBV infection. Therefore, anti-viral therapy for anti-HCV positive hepatic failure should be considered.
采用ORTHO试剂盒对100名献血者和受血者以及374例病毒性肝炎患者进行了抗丙型肝炎病毒检测，其中包括65例暴发性、亚急性和慢性肝衰竭患者。100名献血者和受血者中无一例抗丙型肝炎病毒反应呈阳性。慢性持续性肝炎患者中抗丙型肝炎病毒阳性率为7.6%，慢性活动性肝炎患者中为9.7%，肝硬化患者中为23.1%。在亚急性肝衰竭（60.8%）和慢性肝衰竭（53.9%）中观察到较高的抗丙型肝炎病毒患病率。62例抗丙型肝炎病毒阳性病例中有52例（83.9%）同时感染了乙肝病毒。丙型肝炎病毒感染或合并感染乙肝病毒患者中乙肝病毒复制标志物的发生率低于单纯乙肝病毒感染患者。提示丙型肝炎病毒可能抑制乙型肝炎病毒的复制。抗丙型肝炎病毒阳性肝衰竭患者的死亡率高于乙肝病毒感染患者。因此，应考虑对抗丙型肝炎病毒阳性肝衰竭患者进行抗病毒治疗。
