Huang Y Z, Qian X C, Wang G Q, Gu Y L, Wang S Z, Cheng Z H, Xiao B Y, Gang J M, Wu J Y, Kan M Y
Department of Dermatology, First Affiliated Hospital, Xinjiang Medical College, Urumqi.
Chin Med J (Engl). 1992 Jul;105(7):586-90.
Sixty-five patients in Xinjiang with syndrome of endemic arsenism and fluorosis (SEAF) were investigated clinically from March 1982 to August 1989. SEAF is a kind of chronic syndrome resulting from the combined, harmful effects of two trace elements, arsenic and fluorine. Peripheral neuritis and cardiovascular changes were observed in this syndrome more often than in simple arsenism or simple fluorosis. The excessive quantities of these two trace elements in blood might have a synergic, harmful effect on the nervous and circulatory systems. No definite conclusion could be reached with regard to the morbidity of skin and visceral tumors in this series. The incidence of associated skin cancer was found to be 7.7% and an associated Grade II squamous cell carcinoma of the esophagus was encountered in one patient.
1982年3月至1989年8月，对新疆65例地方性砷中毒和氟中毒综合征（SEAF）患者进行了临床调查。SEAF是一种由砷和氟这两种微量元素的联合有害作用导致的慢性综合征。与单纯砷中毒或单纯氟中毒相比，该综合征中周围神经炎和心血管变化更为常见。血液中这两种微量元素过量可能对神经和循环系统产生协同有害作用。关于该系列中皮肤和内脏肿瘤的发病率，未能得出明确结论。发现相关皮肤癌的发生率为7.7%，并且有1例患者出现了相关的食管II级鳞状细胞癌。
