Máiquez Asuero P, Abadín Delgado J A, Jiménez Plata C, Sánchez Romero A, Durán Quintana J A
Hospital Universitario Virgen Macarena. Sevilla, Spain.
An Med Interna. 2003 Aug;20(8):399-402.
To quantify and analyze suspected and actual digoxin intoxications.
A drug-use study has been carried out of digoxinaemia requests and results in patients treated chronically with digoxin.
Digoxin intoxication (presence of symptoms and typical signs) was suspected in 31.3% of the patients. The percentage analytically confirmed intoxications (digoxinaemia >2 ng/mL) was 16.6%. Sex, age, and dosage had no significant effect in the suspicion or confirmation of digoxin intoxication. Hospitalization and the association of hypokalaemic drugs or those increasing digoxinaemia had no effect in the suspicion of digoxin intoxication. In analytically confirmed intoxications, no significant differences were found between suspected and non-suspected cases.
The suspicion of this intoxications is not usually related with digoxin serum levels, and thus, the toxic limit is imprecise.
对疑似和实际发生的地高辛中毒进行量化和分析。
对长期接受地高辛治疗患者的地高辛血药浓度检测申请及结果开展了一项用药研究。
31.3%的患者被怀疑发生地高辛中毒（出现症状和典型体征）。经分析确认的中毒百分比（地高辛血药浓度>2 ng/mL）为16.6%。性别、年龄和剂量对怀疑或确认地高辛中毒没有显著影响。住院以及联用低钾血症药物或增加地高辛血药浓度的药物对怀疑地高辛中毒没有影响。在经分析确认的中毒病例中，疑似病例和非疑似病例之间未发现显著差异。
对这种中毒的怀疑通常与地高辛血清水平无关，因此，中毒限量并不精确。
