Horowitz Jeffrey F
Division of Kinesiology, The University of Michigan, Ann Arbor, MI 48109-2214, USA.
Trends Endocrinol Metab. 2003 Oct;14(8):386-92. doi: 10.1016/s1043-2760(03)00143-7.
By far the largest energy reserve in the human body is adipose tissue triglycerides, and these reserves are an important source of fuel during prolonged endurance exercise. To use this rich source of potential energy during exercise, adipose tissue triglycerides must first be hydrolyzed and the resultant fatty acids delivered to the working muscles. The aims of this review are to describe how exercise alters lipid mobilization from adipose tissue, to identify alternative sources of lipids and to discuss some of the key factors regulating fatty acid mobilization, uptake and oxidation during exercise. The impact of understanding factors involved in the coordinated regulation of lipid mobilization and oxidation during exercise goes far beyond its relevance for endurance exercise performance. A better understanding of the regulation of these processes will facilitate the development of more effective treatment modalities for obesity-related metabolic disorders.
人体中迄今为止最大的能量储备是脂肪组织甘油三酯，这些储备是长时间耐力运动期间重要的燃料来源。为了在运动期间利用这一丰富的潜在能量来源，脂肪组织甘油三酯必须首先被水解，生成的脂肪酸被输送到工作肌肉。本综述的目的是描述运动如何改变脂肪组织中的脂质动员，确定脂质的替代来源，并讨论运动期间调节脂肪酸动员、摄取和氧化的一些关键因素。了解运动期间脂质动员和氧化的协调调节所涉及的因素，其影响远不止于对耐力运动表现的相关性。更好地理解这些过程的调节将有助于开发更有效的肥胖相关代谢紊乱治疗方法。
