Adamis A P, Aiello L P, D'Amato R A
Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.
Angiogenesis. 1999;3(1):9-14. doi: 10.1023/a:1009071601454.
Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macular degeneration. Although numerous relatively rare conditions also exhibit ocular angiogenesis, the aim of this review will be to briefly summarize our current knowledge regarding the clinical and laboratory findings of the most epidemiologically significant diseases. We will also describe current concepts regarding the pathogenesis of ocular angiogenesis. In this review the term 'neovascularization', which is more prevalent in the ophthalmic literature, will be used to describe the development of pathological new vessels and should be considered synonymous with 'angiogenesis'.
在发达国家，眼部血管生成是导致大多数不可逆失明的原因[1]。这种使人衰弱的并发症影响所有年龄组，并是沙眼、早产儿视网膜病变、糖尿病视网膜病变、新生血管性青光眼和年龄相关性黄斑变性等多种广泛疾病的特征。尽管许多相对罕见的病症也表现出眼部血管生成，但本综述的目的是简要总结我们目前关于最具流行病学意义疾病的临床和实验室研究结果的知识。我们还将描述眼部血管生成发病机制的当前概念。在本综述中，眼科文献中更常用的术语“新生血管形成”将用于描述病理性新血管的形成，应被视为与“血管生成”同义。
