Saegusa T, Kon H, Tsuchitani M, Narama I
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Jikken Dobutsu. 1992 Oct;41(4):481-9. doi: 10.1538/expanim1978.41.4_481.
The effects of sex hormone on diabetic conditions were investigated in WBN/Kob strain rats, i.e., castrated or spayed, hormone-treated, and non-treated rats. The effects of sex hormone on glycosuria, body-weight change, glucose tolerance and histopathology of the pancreas were compared among these animals. There were no abnormal changes in these parameters in the non-treated females and estrogen-treated males. The glycosuria began to be observed from the age of about 30 weeks in the non-treated group and from the age of 52 weeks in the castrated group. In the female animals, this symptom began to appear from the age of 55 weeks in the testosterone-treated group and from the age of 72 weeks in the spayed group. Before the onset of the diabetic symptoms, glucose tolerance was impaired in these animals. Body weights of the castrated and estrogen-treated males were lower than that of the non-treated males, especially in the estrogen-treated males. Those of the spayed and testosterone-treated females were much heavier than that of the non-treated females. Testosterone treatment accelerated body-weight gain in the spayed female animals. Histopathological examination of the pancreas revealed atrophy of the aciner tissue and atrophy and disappearance of the islet cells similar to those of the non-treated WBN/Kob male rats in the castrated males, spayed females and testosterone-treated females. However, these changes were not observed in the non-treated females or estrogen-treated males. These findings suggest that female hormone suppressed the onset of hyperglycemia along with glycosuria and male hormone accelerates the onset of hyperglycemia in the WBN/Kob rats.
在WBN/Kob品系大鼠中研究了性激素对糖尿病状况的影响，即去势或绝育、接受激素治疗和未接受治疗的大鼠。比较了这些动物中性激素对糖尿、体重变化、葡萄糖耐量和胰腺组织病理学的影响。未接受治疗的雌性大鼠和接受雌激素治疗的雄性大鼠在这些参数上没有异常变化。未接受治疗的组中约30周龄开始出现糖尿，去势组中52周龄开始出现。在雌性动物中，睾酮治疗组55周龄开始出现这种症状，绝育组72周龄开始出现。在糖尿病症状出现之前，这些动物的葡萄糖耐量受损。去势和接受雌激素治疗的雄性大鼠体重低于未接受治疗的雄性大鼠，尤其是接受雌激素治疗的雄性大鼠。绝育和接受睾酮治疗的雌性大鼠体重比未接受治疗的雌性大鼠重得多。睾酮治疗加速了绝育雌性动物的体重增加。胰腺组织病理学检查显示，去势雄性大鼠、绝育雌性大鼠和接受睾酮治疗的雌性大鼠的腺泡组织萎缩以及胰岛细胞萎缩和消失，类似于未接受治疗的WBN/Kob雄性大鼠。然而，未接受治疗的雌性大鼠或接受雌激素治疗的雄性大鼠未观察到这些变化。这些发现表明，在WBN/Kob大鼠中，雌性激素抑制高血糖症和糖尿的发生，而雄性激素加速高血糖症的发生。
