Kon H, Saegusa T, Tsuchitani M, Narama I
Hamamatsu Seigiken Research Laboratory Co., Ltd., Shizuoka, Japan.
Jikken Dobutsu. 1988 Oct;37(4):429-35. doi: 10.1538/expanim1978.37.4_429.
Almost all the male animals of WBN/Kob rat strain show the diabetic syndrome whereas none of the female animals develop such diseased conditions even at elder age. We investigated the effect of sex hormones on the onset of diabetic syndrome of this rat strain by comparing the results of body weight gain and various clinical tests such as glucose tolerance, serum biochemistry and histopathology of spayed female rats with those of non-treated and sham-operated female animals kept until 88-week-old. Non-treated and sham-operated female animals had shown no abnormal result even at 88-week-old. Spayed female animals began to reveal glucosuria associated with polydipsia and polyuria from 72-week-old, and gradually developed emaciation and cataract. Increased body weight gain, impaired glucose tolerance and lasting hyperglycemia were observed prior to the onset of the symptoms. Pancreatic changes consisted of atrophy of acinar tissue and atrophy or disappearance of islet tissue attributable to clinical data also were detected in spayed female animals. These diabetic syndrome and pancreatic change were analogous to those of aged male WBN/Kob rats but the onset of spayed females was delayed and less severe. Present results suggest that female sex hormones are protective from the onset of diabetic syndrome of WBN/Kob rats.
几乎所有WBN/Kob大鼠品系的雄性动物都表现出糖尿病综合征，而即使在老年，雌性动物也没有出现这种疾病状况。我们通过比较去卵巢雌性大鼠与未处理及假手术处理的雌性动物直至88周龄时的体重增加结果以及各种临床测试结果，如葡萄糖耐量、血清生化和组织病理学，来研究性激素对该大鼠品系糖尿病综合征发病的影响。未处理及假手术处理的雌性动物即使到88周龄也未显示出异常结果。去卵巢雌性动物从72周龄开始出现与多饮多尿相关的糖尿，并逐渐消瘦和出现白内障。在症状出现之前观察到体重增加、葡萄糖耐量受损和持续高血糖。根据临床数据，在去卵巢雌性动物中还检测到胰腺变化，包括腺泡组织萎缩以及胰岛组织萎缩或消失。这些糖尿病综合征和胰腺变化与老年雄性WBN/Kob大鼠的相似，但去卵巢雌性动物的发病延迟且症状较轻。目前的结果表明，雌性激素对WBN/Kob大鼠糖尿病综合征的发病具有保护作用。
