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Rainbow trout cytochrome P-450c17 (17 alpha-hydroxylase/17,20-lyase). cDNA cloning, enzymatic properties and temporal pattern of ovarian P-450c17 mRNA expression during oogenesis.

作者信息

Sakai N, Tanaka M, Adachi S, Miller W L, Nagahama Y

机构信息

Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki, Japan.

出版信息

FEBS Lett. 1992 Apr 13;301(1):60-4. doi: 10.1016/0014-5793(92)80210-8.

DOI:10.1016/0014-5793(92)80210-8
PMID:1451787
Abstract

A cDNA clone encoding cytochrome P-450c17 (17 alpha-hydroxylase/17,20-lyase) was isolated from a rainbow trout ovarian follicle cDNA library. The cDNA contained an open reading frame of 1,542 nucleotides encoding a protein of 514 amino acid residues. The amino acid sequence of trout P-450c17 shows a much greater homology with chicken P-450c17 than with that of human, bovine and rat. The trout P-450c17 expressed in non-steroidogenic mammalian COS-1 cells showed both 17 alpha-hydroxylase and 17,20-lyase activities. The cDNA only hybridized to a single species of mRNA (2.4 kb) isolated from rainbow trout ovaries; the 2.4 kb transcripts were abundant in trout ovaries during the later stages of oogenesis.

摘要

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