Shakoori A R, Aslam F, Sabir M, Ali S S
Department of Zoology, University of the Punjab, Lahore, Pakistan.
Folia Biol (Krakow). 1992;40(1-2):91-9.
A sublethal dose of Karate administered to rabbits produced a significant increase in the total erythrocyte count and packed cell volume after 15 days of administration, though no significant change was observed after 30 days. The transaminases (glutamate oxaloacetate transaminase, GOT; glutamate pyruvate transaminase, GPT) also increased after 15 days of treatment. The GPT activity increased 119% and 60% after 15 and 30 days, respectively. From amongst metabolites, glucose content increased 17% and 185%, while cholesterol decreased 40% and 66%, and bilirubin 84% and 61%, after 15 and 30 days, respectively. The hepatic AkP activity decreased 30%, while the GPT activity increased 44%. Other enzymes such as AcP, GOT and LDH remained unaffected. The concentration of other metabolites, except for FAA which increased 35%, remained unaffected. Histological changes were marked by atrophied hepatic cells and hypertrophied nuclei and nucleoli. A trend towards necrosis of hepatic cells was also observed. All these results indicate that Karate is moderately toxic to mammals.
给兔子施用亚致死剂量的空手道（Karate，可能是某种药物名称）后，给药15天后红细胞总数和红细胞压积显著增加，不过30天后未观察到显著变化。治疗15天后转氨酶（谷草转氨酶，GOT；谷丙转氨酶，GPT）也升高。GPT活性在15天和30天后分别增加了119%和60%。在代谢物中，葡萄糖含量在15天和30天后分别增加了17%和185%，而胆固醇分别降低了40%和66%，胆红素分别降低了84%和61%。肝脏碱性磷酸酶（AkP）活性降低了30%，而GPT活性增加了44%。其他酶如酸性磷酸酶（AcP）、GOT和乳酸脱氢酶（LDH）未受影响。除游离脂肪酸（FAA）增加了35%外，其他代谢物的浓度未受影响。组织学变化表现为肝细胞萎缩以及细胞核和核仁肥大。还观察到肝细胞有坏死的趋势。所有这些结果表明空手道对哺乳动物有中度毒性。
