Hossen Md Sakib, Billah Prince Md Maruf, Tanvir E M, Chowdhury M Alamgir Zaman, Rahman Md Abdur, Alam Fahmida, Paul Sudip, Saha Moumoni, Ali Md Yousuf, Bhoumik Nikhil Chandra, Karim Nurul, Gan Siew Hua, Khalil Md Ibrahim
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Department of Biochemistry, Primeasia University, Banani, Dhaka 1213, Bangladesh.
Evid Based Complement Alternat Med. 2018 May 15;2018:6254929. doi: 10.1155/2018/6254929. eCollection 2018.
The current study aimed to investigate the ameliorative effects of two types of mushrooms, (GL) and (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats ( = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively. In the CF alone treated group, there were significant decreases in the erythrocytic and thrombocytic indices but increases in the concentrations of the total leukocytes, including the agranulocytes. A significant increase in all of the liver function biomarkers except albumin, in lipid profiles except high-density lipoprotein, and in the kidney function markers occurred in the negative control group compared to the rats of the normal control and positive control groups. The coadministration of mushroom extracts significantly ameliorated the toxic effects of the CF. The GL mushroom extract was more efficacious than that of the AP mushroom, possibly due to the presence of high levels of phenolic compounds and other antioxidants in the GL mushroom.
本研究旨在探究两种蘑菇，即姬松茸（GL）和糙皮侧耳（AP）对大鼠体内克百威（CF）诱导毒性的改善作用。将42只雄性Wistar大鼠平均分为六组。阴性对照组大鼠以1 mg/kg的剂量口服CF，并给予正常饮食，持续28天。治疗组大鼠分别以100 mg/kg的剂量口服GL或AP的乙醇提取物，随后在相同实验期间以1 mg/kg的剂量口服CF，并给予正常饮食。在仅用CF处理的组中，红细胞和血小板指标显著降低，但包括无粒细胞在内的总白细胞浓度升高。与正常对照组和阳性对照组的大鼠相比，阴性对照组的所有肝功能生物标志物（白蛋白除外）、脂质谱（高密度脂蛋白除外）和肾功能标志物均显著升高。蘑菇提取物的共同给药显著改善了CF的毒性作用。姬松茸提取物比糙皮侧耳提取物更有效，这可能是由于姬松茸中含有高水平的酚类化合物和其他抗氧化剂。
