Kobayashi K, Katayama Y, Kasai M, Oshima H, Fukaya C, Yamamoto T
Department Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
Acta Neurochir Suppl. 2003;87:137-9. doi: 10.1007/978-3-7091-6081-7_29.
It has been reported that parkinsonian and essential tremor can be controlled by deep brain stimulation or radiofrequency lesion within the cluster of cells with a tremor-frequency activity in the ventral thalamic nuclei. However, there have been very few reports about the exact localization of cells with tremor-frequency activity in the ventral thalamic nuclei. In the present study, we investigated the localization of cells with tremor-frequency activity in the ventral thalamic nuclei employing autopower spectrum and coherence analysis. Activity of a total of 130 cells, 63 in patients with parkinsonian tremor and 67 in patients with essential tremor, were recorded from the area anterior to the nucleus ventralis caudalis. Among these cells, 31 cells showed a coherence of greater than 0.4 to the electromyographic activity of both agonist and antagonist muscles. The proportion of cells exhibiting tremor-frequency activity were 26.8% in the nucleus ventralis intermedius (Vim) and 25.0% in the nuclei ventralis oralis posterior et anterior (Vop + Voa). There were no significant differences in proportion by nuclear location or disease. The present study demonstrated that cells with tremor-frequency activity are widely distributed over the area extending from the Vim to the Vop + Voa. This indicates that the best location for placing electrodes for deep brain stimulation or a radiofrequency lesion cannot be defined by identification of cells with tremor-frequency activity alone.
据报道，帕金森病性震颤和特发性震颤可通过丘脑腹侧核团中具有震颤频率活动的细胞群内的深部脑刺激或射频毁损来控制。然而，关于丘脑腹侧核团中具有震颤频率活动的细胞的确切定位的报道却非常少。在本研究中，我们采用自功率谱和相干分析来研究丘脑腹侧核团中具有震颤频率活动的细胞的定位。从尾侧腹核前方区域记录了总共130个细胞的活动，其中帕金森病性震颤患者63个，特发性震颤患者67个。在这些细胞中，31个细胞与主动肌和拮抗肌的肌电图活动的相干性大于0.4。在中间腹核（Vim）中表现出震颤频率活动的细胞比例为26.8%，在丘脑后腹侧核和前腹侧核（Vop + Voa）中为25.0%。按核位置或疾病分类，比例无显著差异。本研究表明，具有震颤频率活动的细胞广泛分布于从Vim到Vop + Voa的区域。这表明，仅通过识别具有震颤频率活动的细胞不能确定深部脑刺激或射频毁损电极的最佳放置位置。
