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1
Investigation of deep brain stimulation mechanisms during implantable pulse generator replacement surgery.植入式脉冲发生器更换手术期间深部脑刺激机制的研究。
Neuromodulation. 2014 Jul;17(5):419-24; discussion 424. doi: 10.1111/ner.12123. Epub 2013 Oct 7.
2
Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation.通过丘脑刺激对特发性震颤震颤幅度进行的相位依赖性调制。
Brain. 2013 Oct;136(Pt 10):3062-75. doi: 10.1093/brain/awt239. Epub 2013 Sep 14.
3
Effects of low-frequency thalamic deep brain stimulation in essential tremor patients.低频丘脑深部电刺激对特发性震颤患者的影响。
Exp Neurol. 2013 Oct;248:205-12. doi: 10.1016/j.expneurol.2013.06.009. Epub 2013 Jun 15.
4
Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease.提高帕金森病的时间非规则性脑深部刺激的疗效。
Exp Neurol. 2013 Jan;239:60-7. doi: 10.1016/j.expneurol.2012.09.008. Epub 2012 Sep 27.
5
An algorithm for management of deep brain stimulation battery replacements: devising a web-based battery estimator and clinical symptom approach.一种深部脑刺激电池更换管理算法：设计基于网络的电池估算器和临床症状方法。
Neuromodulation. 2013 Mar-Apr;16(2):147-53. doi: 10.1111/j.1525-1403.2012.00457.x. Epub 2012 May 30.
6
The tremor network targeted by successful VIM deep brain stimulation in humans.人类中成功的 VIM 深部脑刺激靶向的震颤网络。
Neurology. 2012 Mar 13;78(11):787-95. doi: 10.1212/WNL.0b013e318249f702. Epub 2012 Feb 29.
7
Closed-loop deep brain stimulation is superior in ameliorating parkinsonism.闭环深部脑刺激在改善帕金森病方面更优。
Neuron. 2011 Oct 20;72(2):370-84. doi: 10.1016/j.neuron.2011.08.023.
8
Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation.与时间模式化的深部脑刺激相关的震颤抑制减少的刺激特征。
J Neurophysiol. 2012 Jan;107(1):364-83. doi: 10.1152/jn.00906.2010. Epub 2011 Oct 12.
9
Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation.在周期性丘脑深部脑刺激过程中震颤的减少和模拟神经活动。
Clin Neurophysiol. 2012 May;123(5):1044-52. doi: 10.1016/j.clinph.2011.07.052. Epub 2011 Oct 5.
10
Individual fiber anatomy of the subthalamic region revealed with diffusion tensor imaging: a concept to identify the deep brain stimulation target for tremor suppression.应用弥散张量成像显示的丘脑底核的个体纤维解剖结构：用于识别抑制震颤的深部脑刺激靶点的概念。
Neurosurgery. 2011 Apr;68(4):1069-75; discussion 1075-6. doi: 10.1227/NEU.0b013e31820a1a20.

丘脑深部脑刺激中的短暂停顿会促进震颤和神经元爆发。

Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting.

作者信息

Swan Brandon D, Brocker David T, Hilliard Justin D, Tatter Stephen B, Gross Robert E, Turner Dennis A, Grill Warren M

机构信息

Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Department of Neurosurgery, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA.

出版信息

Clin Neurophysiol. 2016 Feb;127(2):1551-1559. doi: 10.1016/j.clinph.2015.07.034. Epub 2015 Aug 20.

DOI:10.1016/j.clinph.2015.07.034
PMID:26330131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4747847/
Abstract

OBJECTIVE

We conducted intraoperative measurements of tremor during DBS containing short pauses (⩽50 ms) to determine if there is a minimum pause duration that preserves tremor suppression.

METHODS

Nine subjects with ET and thalamic DBS participated during IPG replacement surgery. Patterns of DBS included regular 130 Hz stimulation interrupted by 0, 15, 25 or 50 ms pauses. The same patterns were applied to a model of the thalamic network to quantify effects of pauses on activity of model neurons.

RESULTS

All patterns of DBS decreased tremor relative to 'off'. Patterns with pauses generated less tremor reduction than regular high frequency DBS. The model revealed that rhythmic burst-driver inputs to thalamus were masked during DBS, but pauses in stimulation allowed propagation of bursting activity. The mean firing rate of bursting-type model neurons as well as the firing pattern entropy of model neurons were both strongly correlated with tremor power across stimulation conditions.

CONCLUSIONS

The temporal pattern of stimulation influences the efficacy of thalamic DBS. Pauses in stimulation resulted in decreased tremor suppression indicating that masking of pathological bursting is a mechanism of thalamic DBS for tremor.

SIGNIFICANCE

Pauses in stimulation decreased the efficacy of open-loop DBS for suppression of tremor.

摘要

目的

我们在包含短暂停顿（≤50毫秒）的脑深部电刺激（DBS）过程中进行了震颤的术中测量，以确定是否存在能保持震颤抑制的最短停顿持续时间。

方法

9名患有特发性震颤（ET）且接受丘脑DBS治疗的受试者在植入式脉冲发生器（IPG）更换手术期间参与研究。DBS模式包括以0、15、25或50毫秒的停顿打断的130赫兹常规刺激。将相同模式应用于丘脑网络模型，以量化停顿对模型神经元活动的影响。

结果

所有DBS模式相对于“关闭”状态均降低了震颤。有停顿的模式产生的震颤减轻程度低于常规高频DBS。该模型显示，在DBS期间，丘脑的节律性爆发驱动输入被掩盖，但刺激停顿允许爆发活动传播。在不同刺激条件下，爆发型模型神经元的平均放电率以及模型神经元的放电模式熵均与震颤功率密切相关。

结论

刺激的时间模式会影响丘脑DBS的疗效。刺激停顿导致震颤抑制作用减弱，表明病理性爆发的掩盖是丘脑DBS治疗震颤的一种机制。

意义

刺激停顿降低了开环DBS抑制震颤的疗效。

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