Söling Ariane, Rainov Nikolai G
Molecular Neurooncology Laboratory, ZAMED, Heinrich-Damerow-Strasse 1, 06097, Halle, Germany.
Expert Opin Biol Ther. 2003 Oct;3(7):1163-72. doi: 10.1517/14712598.3.7.1163.
Molecular events promoting tumourigenesis and anticancer therapeutic strategies have been intensively studied in tumour cell culture models. In the past few years, non-invasive bioluminescence imaging (BLI) has emerged as a powerful strategy for the validation of cell culture findings in animal models of cancer. BLI allows for repetitive and exceptionally sensitive real-time monitoring of a disease course, as well as of tumour response to therapeutic interventions in an individual animal. This review discusses the application of BLI to cancer research in general and to the area of experimental neuro-oncology in particular.
在肿瘤细胞培养模型中，对促进肿瘤发生的分子事件和抗癌治疗策略进行了深入研究。在过去几年中，非侵入性生物发光成像（BLI）已成为在癌症动物模型中验证细胞培养结果的有力策略。BLI能够对疾病进程以及单个动物肿瘤对治疗干预的反应进行重复且极其灵敏的实时监测。本综述讨论了BLI在一般癌症研究中的应用，特别是在实验性神经肿瘤学领域的应用。
