Sorahan T, Haylock R G E, Muirhead C R, Bunch K J, Kinlen L J, Little M P, Draper G J, Kendall G M, Lancashire R J, English M A
Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Br J Cancer. 2003 Oct 6;89(7):1215-20. doi: 10.1038/sj.bjc.6601273.
An earlier case-control study found no evidence of paternal preconceptional irradiation (PPI) as a cause of childhood leukaemia and non-Hodgkin's lymphoma (LNHL). Although fathers of children with LNHL were more likely to have been radiation workers, the risk was most marked in those with doses below the level of detection. The timing of paternal employment as a radiation worker has now been examined. The previously reported elevated risk of LNHL in the children of male radiation workers was limited to those whose fathers were still radiation workers at conception or whose employment also continued until diagnosis. Children whose fathers stopped radiation work prior to their conception were found to have no excess risk of LNHL. It was not possible to distinguish between the risks associated with paternal radiation work at conception and at the time of diagnosis. A reanalysis of the original study hypothesis incorporating updated dosimetric information gave similar results to those obtained previously. In particular, the risks of LNHL did not show an association with radiation doses received by the father before conception. It seems likely that the increased risk of LNHL among the children of male radiation workers is associated with an increased exposure to some infective agent consequent on high levels of population mixing.
一项早期的病例对照研究未发现父亲孕前接受辐射（PPI）是儿童白血病和非霍奇金淋巴瘤（LNHL）病因的证据。尽管LNHL患儿的父亲更有可能是辐射工作者，但风险在那些剂量低于检测水平的人群中最为明显。现在已经对父亲作为辐射工作者的就业时间进行了研究。先前报告的男性辐射工作者子女患LNHL风险升高仅限于那些其父亲在受孕时仍是辐射工作者或其工作也持续到诊断之时的情况。发现其父亲在受孕前停止辐射工作的儿童没有LNHL的额外风险。无法区分受孕时和诊断时父亲辐射工作相关的风险。结合更新的剂量测定信息对原始研究假设进行重新分析，得到了与之前相似的结果。特别是，LNHL的风险与父亲受孕前接受的辐射剂量没有关联。男性辐射工作者子女中LNHL风险增加似乎与因高度人群混合导致接触某种感染因子增加有关。
