Dasari Sonali S, Archer Maddison, Mohamed Nihal E, Tewari Ashutosh K, Figueiro Mariana G, Kyprianou Natasha
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Tisch Cancer Institute, Mount Sinai Health, New York, NY 10029, USA.
Cancers (Basel). 2022 Oct 19;14(20):5116. doi: 10.3390/cancers14205116.
In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer.
在美国，非裔美国男性因前列腺癌导致的死亡率是白人男性的2.4倍。前列腺癌种族差异的多因素成因涉及各种健康的社会决定因素、社会经济地位以及医疗保健可及性。然而，新出现的证据也表明，昼夜节律紊乱（CRD）会促使前列腺癌的发生，且非裔美国男性可能更容易出现昼夜节律紊乱。昼夜节律在新陈代谢、激素分泌以及睡眠/觉醒周期中起着重要作用。这些昼夜节律的紊乱可能由飞机旅行/时差反应、夜班工作、光照暴露以及邻里噪音水平引起，进而导致睡眠障碍以及肥胖、糖尿病、心血管疾病和抑郁症等慢性疾病。昼夜节律紊乱种族差异的驱动因素包括夜班工作、种族歧视、压力升高以及居住在噪音污染严重的贫困社区。鉴于非裔美国男性更容易出现昼夜节律紊乱，以及昼夜节律紊乱在前列腺癌中所起的作用，阐明与生物钟相关的前列腺癌途径及其行为和环境协变量，对于更好地理解和减少前列腺癌的种族差异可能至关重要。
