Rujjanawate C, Kanjanapothi D, Panthong A
Laboratory of Natural Products, Faculty of Medicine, Chulabhorn Research Institute, Research Center at Chiangmai University, Chiangmai University, Chiangmai 50200, Thailand.
J Ethnopharmacol. 2003 Nov;89(1):91-5. doi: 10.1016/s0378-8741(03)00267-8.
Gelsemium elegans Benth. (Loganiaceae), a toxic plant indigenous to southeastern Asia, is well known among hilltribes as an effective means for committing suicide. A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction. Tests in animals showed that the alkaloids exerted analgesic and anti-inflammatory effects. At a lethal dose, the alkaloids produced violent clonic convulsions that led to respiratory failure. Since the convulsions could be prevented by pentobarbital or diazepam and potentiated by reserpine, it is postulated that the alkaloids act centrally against GABA action.
钩吻（马钱科），一种原产于东南亚的有毒植物，在山地部落中作为一种有效的自杀手段而广为人知。通过常规酸碱提取法从其叶子中分离出一种粗生物碱馏分。动物实验表明，这些生物碱具有镇痛和抗炎作用。在致死剂量下，生物碱会引发剧烈的阵挛性惊厥，导致呼吸衰竭。由于戊巴比妥或地西泮可预防惊厥，而利血平可增强惊厥，因此推测这些生物碱通过中枢作用对抗γ-氨基丁酸（GABA）的作用。
