孕妇的乙型肝炎病毒感染及其母婴传播。
Hepatitis B virus infection in pregnant mothers and its transmission to infants.
作者信息
Akhter S, Talukder M Q, Bhuiyan N, Chowdhury T A, Islam M N, Begum S
机构信息
Department of Pediatrics, IPGM & R, Dhaka, Bangla Desh.
出版信息
Indian J Pediatr. 1992 Jul-Aug;59(4):411-5. doi: 10.1007/BF02751551.
Screening for serological markers of hepatitis B virus infection was done on 500 pregnant mothers. HBsAg, AntiHBs and HBeAg were done. HBsAg was positive in 3.6%, AntiHBs in 17.4% and HBeAg in 0.4% cases. The infants born to the asymptomatic HBsAg carrier mothers were followed up to 6 months to determine the vertical transmission of HBV infection. Rate of transmission of infection from HBsAg positive mothers to infants were 16.66% irrespective of HBeAg status, whereas it was nearly 100% in case of HBeAg positive mothers. All of the HBsAg positive infants developed the antigenemia between 3-6 months of age, supporting the hypothesis that intrapartum transmission is the major mode of vertical transmission.
对500名孕妇进行了乙肝病毒感染血清学标志物筛查。检测了乙肝表面抗原（HBsAg）、乙肝表面抗体（AntiHBs）和乙肝e抗原（HBeAg）。HBsAg阳性率为3.6%，AntiHBs阳性率为17.4%，HBeAg阳性率为0.4%。对无症状HBsAg携带者母亲所生婴儿进行了长达6个月的随访，以确定乙肝病毒感染的垂直传播情况。无论HBeAg状态如何，HBsAg阳性母亲将感染传播给婴儿的比率为16.66%，而HBeAg阳性母亲的传播率近100%。所有HBsAg阳性婴儿在3至6个月大时出现抗原血症，支持了分娩时传播是垂直传播主要方式这一假说。
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