Kisakol Gurcan, Kayacetin Ertugrul, Sari Oktay, Kaya Ahmet
Selcuk University Meram Medical Faculty, Internal Medicine, Division of Endocrinology and Metabolism, Konya, Turkey.
Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):255-8.
About 15% of hyperthyroid patients suffer from gastrointestinal symptoms such as diarrhea, constipation, nausea and early satiety the problem. Published reports on the topic of gastric emptying in hyperthyroidism are rare and discrepant in their results.
Thirteen patients (8 women, 5 male; aged 41.92+/-1.491 SE yr) with a recently established diagnosis of subclinical hyperthyroidism due to Graves-Basedow disease and as control group 10 age-matched healthy subject (7 women, 3 male; 39.6+/-2.918 SE yrs) participated in this study. Scintigraphic method (food labeled with 99mTc sulfur colloid) was used for measurement of gastric emptying.
Gastric emptying time was similar in both subclinical hyperthyroid and control groups (p=0.413).
There are few studies on the subject of gastric emptying in hyperthyroidism with either delayed emptying or with emptying time similar to controls. In the only one study in subclinical hyperthyroidism, gastric emptying was found to be delayed. We also found that gastric emptying was delayed in subclinical hyperthyroidism. On the basis of this and other studies, we may suggest that in subclinical hyperthyroidism, gastric emptying of solids were similar to that in age-matched healthy control subjects and gastrointestinal dysfunction is dependent on severity of the hyperthyroid state and might be a result of impaired neuro-hormonal regulation. Yet the data must be supported on larger groups.
约15%的甲状腺功能亢进患者存在诸如腹泻、便秘、恶心和早饱等胃肠道症状问题。关于甲状腺功能亢进症患者胃排空这一主题的已发表报告很少，且结果存在差异。
13例因格雷夫斯 - 巴塞多氏病新近确诊为亚临床甲状腺功能亢进症的患者（8例女性，5例男性；年龄41.92±1.491标准误岁）以及作为对照组的10例年龄匹配的健康受试者（7例女性，3例男性；39.6±2.918标准误岁）参与了本研究。采用闪烁扫描法（用99mTc硫胶体标记食物）测量胃排空。
亚临床甲状腺功能亢进组和对照组的胃排空时间相似（p = 0.413）。
关于甲状腺功能亢进症患者胃排空这一主题的研究很少，要么胃排空延迟，要么排空时间与对照组相似。在唯一一项关于亚临床甲状腺功能亢进症的研究中，发现胃排空延迟。我们也发现亚临床甲状腺功能亢进症患者胃排空延迟。基于本研究及其他研究，我们可能提示，在亚临床甲状腺功能亢进症中，固体食物的胃排空与年龄匹配的健康对照受试者相似，胃肠道功能障碍取决于甲状腺功能亢进状态的严重程度，可能是神经 - 激素调节受损的结果。然而，这些数据必须在更大规模的人群中得到支持。
