Annese V, Bassotti G, Napolitano G, Frusciante V, Bruno M, Conoscitore P, Germani U, Morelli A, Andriulli A
Divisione di Gastroenterologia, Ospedale Casa-Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy.
J Clin Gastroenterol. 1995 Dec;21(4):279-82. doi: 10.1097/00004836-199512000-00005.
To date, only a few studies of gastric emptying in Crohn's disease have been published in the literature. This might be clinically important because slow-release drug formulations are increasingly available for treatment. Studies in children with gastric involvement suggest that gastric emptying may be delayed in this condition. We studied the scintigraphic gastric emptying of 21 adult patients with nonobstructive Crohn's disease and without gastric or duodenal involvement by the disease, compared with that of 20 healthy volunteers. Overall, no significant differences were found, but subgroup analysis showed that symptomatic patients [half-time (t1/2) 133 +/- 75.9] and those with colonic involvement (t1/2 127.2 +/- 64) had a significantly (p < 0.01) delayed gastric emptying over controls (t1/2 85.5 +/- 15.4). Such a difference was also observed between symptomatic and asymptomatic patients (p < 0.05). We conclude that gastric emptying is slowed in symptomatic patients with nonobstructive Crohn's disease and in those with colonic involvement. This may have therapeutic implications.
迄今为止，文献中仅发表了少数关于克罗恩病患者胃排空的研究。这在临床上可能很重要，因为缓释药物制剂越来越多地用于治疗。对有胃部受累的儿童进行的研究表明，这种情况下胃排空可能会延迟。我们研究了21例无梗阻性克罗恩病且无胃部或十二指肠受累的成年患者的闪烁扫描胃排空情况，并与20名健康志愿者进行了比较。总体而言，未发现显著差异，但亚组分析显示，有症状的患者[半衰期（t1/2）为133±75.9]和有结肠受累的患者（t1/2为127.2±64）的胃排空明显（p<0.01）延迟，超过了对照组（t1/2为85.5±15.4）。有症状和无症状患者之间也观察到了这种差异（p<0.05）。我们得出结论，有症状的无梗阻性克罗恩病患者以及有结肠受累的患者胃排空减慢。这可能具有治疗意义。
