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远缘链球菌B13的一种87千道尔顿葡聚糖结合蛋白。

An 87-kilodalton glucan-binding protein of Streptococcus sobrinus B13.

作者信息

Wu-Yuan C D, Gill R E

机构信息

Dows Institute for Dental Research, University of Iowa College of Dentistry, Iowa City 52242.

出版信息

Infect Immun. 1992 Dec;60(12):5291-3. doi: 10.1128/iai.60.12.5291-5293.1992.

DOI:10.1128/iai.60.12.5291-5293.1992
PMID:1452362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258308/
Abstract

An 87-kDa glucan-binding protein (GBP) of Streptococcus sobrinus B13 (serotype d) was isolated and purified from extracellular culture supernatant by using affinity chromatography on Sephadex G-50 and elution with a guanidine HCl gradient. Western blot (immunoblot) analysis showed it to be antigenically related, but not completely identical, to the 74-kDa GBP of Streptococcus mutans Ingbritt. The 87-kDa GBP has no glucosyltransferase activity. A possible role for this GBP in the cariogenicity of S. sobrinus B13 is suggested.

摘要

从远缘链球菌B13（血清型d）的细胞外培养上清液中，通过在葡聚糖凝胶G - 50上进行亲和层析并用盐酸胍梯度洗脱，分离并纯化出一种87 kDa的葡聚糖结合蛋白（GBP）。蛋白质免疫印迹（免疫印迹）分析表明，它与变形链球菌Ingbritt的74 kDa GBP在抗原性上相关，但并不完全相同。87 kDa的GBP没有葡糖基转移酶活性。提示了这种GBP在远缘链球菌B13致龋性中的可能作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/258308/d38ea8b9ec44/iai00036-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/258308/0178afd04c22/iai00036-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/258308/d38ea8b9ec44/iai00036-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/258308/0178afd04c22/iai00036-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/258308/d38ea8b9ec44/iai00036-0327-a.jpg

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