Cruz S A, Karaçorlu M, Peyman G A
LSU Eye Center, Louisiana State University Medical Center, School of Medicine, New Orleans 70122-2234.
Int Ophthalmol. 1992 May;16(3):153-7. doi: 10.1007/BF00916434.
The 21-aminosteroids or lazaroids are a novel series of compounds being developed for the acute treatment of traumatic or ischemic injury of the nervous system. These compounds were specifically designed to localize within cell membranes and inhibit lipid peroxidation reactions. In this study, 21-aminosteroid U75412E was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 20 micrograms to 200 micrograms. Retinal toxicity was determined through light and transmission electron microscopy and electroretinography. No retinal toxicity was noted in doses of 30 micrograms and below.
21-氨基类固醇或拉扎罗ids是正在开发用于急性治疗神经系统创伤或缺血性损伤的新型化合物系列。这些化合物经过专门设计，可定位于细胞膜内并抑制脂质过氧化反应。在本研究中，将21-氨基类固醇U75412E注入兔眼玻璃体，以评估其眼内注射的适用性及其对眼内组织的毒性。剂量范围为20微克至200微克。通过光学和透射电子显微镜以及视网膜电图测定视网膜毒性。30微克及以下剂量未观察到视网膜毒性。
