Thompson Larry O, Loebe Matthias, Noon George P
Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA.
ASAIO J. 2003 Sep-Oct;49(5):518-26. doi: 10.1097/01.mat.0000085672.42122.49.
Use of ventricular support systems has been associated with myriad systemic complications. Engendered by the blood-biomaterial interface of a unique host/device relationship, these complications include diverse humoral dyscrasias that frequently culminate in episodes of bleeding, hemolysis and thrombogenicity, heightened susceptibility to inflammation and infection, and transient immunal compromise. Recent endeavor in biocompatibility research has served to illustrate the critical role played by cellular, humoral, and neurohormonal components in regulating cytokine expression and has provided insight into the complexities involved in such biomechanical juxtapositions. The following is intended as a review of current literature attempting to address the many aspects of this host/device interaction and their consequences for the supported patient.
心室支持系统的使用与众多全身并发症相关。这些并发症由独特的宿主/装置关系中的血液-生物材料界面引发，包括各种体液异常，常导致出血、溶血和血栓形成等情况，对炎症和感染的易感性增加，以及短暂的免疫功能损害。生物相容性研究的最新努力已表明细胞、体液和神经激素成分在调节细胞因子表达中所起的关键作用，并深入了解了这种生物力学并列关系中涉及的复杂性。以下旨在综述当前文献，试图探讨这种宿主/装置相互作用的诸多方面及其对接受支持治疗患者的影响。
