Wu Wei-Tao, Aubry Nadine, Massoudi Mehrdad, Kim Jeongho, Antaki James F
Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Department of Mechanical Engineering, Northeastern University, Boston, MA 02115, USA.
Int J Eng Sci. 2014 Mar 1;76:56-72. doi: 10.1016/j.ijengsci.2013.12.001.
In this paper, we consider the two dimensional flow of blood in a rectangular microfluidic channel. We use Mixture Theory to treat this problem as a two-component system: One component is the red blood cells (RBCs) modeled as a generalized Reiner-Rivlin type fluid, which considers the effects of volume fraction (hematocrit) and influence of shear rate upon viscosity. The other component, plasma, is assumed to behave as a linear viscous fluid. A CFD solver based on OpenFOAM was developed and employed to simulate a specific problem, namely blood flow in a two dimensional micro-channel, is studied. Finally to better understand this two-component flow system and the effects of the different parameters, the equations are made dimensionless and a parametric study is performed.
在本文中,我们考虑矩形微流体通道内的二维血液流动。我们运用混合理论将此问题视为一个双组分系统:一个组分是红细胞(RBCs),将其建模为广义的Reiner-Rivlin型流体,该模型考虑了体积分数(血细胞比容)的影响以及剪切速率对粘度的影响。另一个组分,即血浆,假定其表现为线性粘性流体。开发了基于OpenFOAM的计算流体动力学(CFD)求解器,并用于模拟一个特定问题,即二维微通道内的血液流动。最后,为了更好地理解这个双组分流动系统以及不同参数的影响,对方程进行无量纲化并开展参数研究。