Astumian R Dean
University of Maine, Orono, Maine 04469-5709, USA.
Phys Rev Lett. 2003 Sep 12;91(11):118102. doi: 10.1103/PhysRevLett.91.118102.
An ion motive ATPase is a membrane protein that pumps ions across the membrane at the expense of the chemical energy of adenosine triphosphate (ATP) hydrolysis. Here we describe how an external electric field, by inducing transitions between several protein configurations, can also power this pump. The underlying mechanism may be very similar to that of a recently constructed adiabatic electron pump [Science 283, 1905 (1999)]].
离子动力ATP酶是一种膜蛋白，它利用三磷酸腺苷（ATP）水解的化学能将离子泵过膜。在这里，我们描述了外部电场如何通过诱导几种蛋白质构象之间的转变来为这种泵提供动力。其潜在机制可能与最近构建的绝热电子泵[《科学》283, 1905 (1999)]的机制非常相似。
