CPx型ATP酶：一类负责转运重金属的P型ATP酶。
CPx-type ATPases: a class of P-type ATPases that pump heavy metals.
作者信息
Solioz M, Vulpe C
机构信息
Department of Clinical Pharmacology, University of Berne, Switzerland.
出版信息
Trends Biochem Sci. 1996 Jul;21(7):237-41.
PMID:8755241
Abstract
ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.
摘要
ATP驱动的重金属泵代表了一类新定义的蛋白质，它们能将有毒和必需的金属转运穿过生物膜。这些转运蛋白形成了离子转运P型ATP酶的一个独立进化分支。基于保守的膜内半胱氨酸-脯氨酸-半胱氨酸或半胱氨酸-脯氨酸-组氨酸基序这一共同的新特征，我们建议将这些酶称为CPx型ATP酶。
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