Head David A, Levine Alex J, MacKintosh F C
Division of Physics & Astronomy, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.
Phys Rev Lett. 2003 Sep 5;91(10):108102. doi: 10.1103/PhysRevLett.91.108102.
Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various cross-linking and other associated proteins largely determine the (visco)elastic response of cells. In this Letter we study a model system of cross-linked, stiff filaments in order to explore the connection between the microstructure under strain and the macroscopic response of cytoskeletal networks. We find two distinct regimes as a function primarily of cross-link density and filament rigidity: one characterized by affine deformation and one by nonaffine deformation. We characterize the crossover between these two.
丝状蛋白质网络在细胞力学中起着至关重要的作用。这些细胞骨架网络，连同各种交联蛋白和其他相关蛋白，在很大程度上决定了细胞的（粘）弹性响应。在本信函中，我们研究了交联刚性细丝的模型系统，以探索应变下微观结构与细胞骨架网络宏观响应之间的联系。我们发现主要作为交联密度和细丝刚性函数的两种不同状态：一种以仿射变形为特征，另一种以非仿射变形为特征。我们对这两者之间的转变进行了表征。
