Roberts Stephen E, Goldacre Michael J
Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Oxford OX3 7LF.
BMJ. 2003 Oct 4;327(7418):771-5. doi: 10.1136/bmj.327.7418.771.
To investigate time trends in mortality after admission to hospital for fractured neck of femur from 1968 to 1998, and to report on the effects of demographic factors on mortality.
Analysis of hospital inpatient statistics for fractured neck of femur, incorporating linkage to death certificates.
Four counties in southern England.
32 590 people aged 65 years or over admitted to hospital with fractured neck of femur between 1968 and 1998.
Case fatality rates at 30, 90, and 365 days after admission, and standardised mortality ratios at monthly intervals up to one year after admission.
Case fatality rates declined between the 1960s and the early 1980s, but there was no appreciable fall thereafter. They increased sharply with increasing age: for example, fatality rates at 30 days in 1984-98 increased from 4% in men aged 64-69 years to 31% in those aged > or = 90. They were higher in men than women, and in social classes IV and V than in classes I and II. In the first month after fracture, standardised mortality ratios in women were 16 times higher, and those in men 12 times higher, than mortality in the same age group in the general population.
The high mortality rates, and the fact that they have not fallen over the past 20 years, reinforce the need for measures to prevent osteoporosis and falls and their consequences in elderly people. Whether post-fracture mortality has fallen to an irreducible minimum, or whether further decline is possible, is unclear.
调查1968年至1998年因股骨颈骨折入院后的死亡率时间趋势,并报告人口统计学因素对死亡率的影响。
对股骨颈骨折的医院住院统计数据进行分析,并与死亡证明建立关联。
英格兰南部的四个县。
1968年至1998年间因股骨颈骨折入院的32590名65岁及以上的老年人。
入院后30天、90天和365天的病死率,以及入院后长达一年的每月标准化死亡比。
20世纪60年代至80年代初病死率有所下降,但此后没有明显下降。病死率随年龄增长而急剧上升:例如,1984 - 1998年30天病死率在64 - 69岁男性中从4%上升至90岁及以上男性中的31%。男性病死率高于女性,社会阶层IV和V高于阶层I和II。骨折后的第一个月,女性标准化死亡比是同年龄组普通人群死亡率的16倍,男性是12倍。
高死亡率以及在过去20年中未下降这一事实,强化了采取措施预防老年人骨质疏松、跌倒及其后果的必要性。骨折后死亡率是否已降至不可再降低的最低水平,或者是否还可能进一步下降,尚不清楚。