Matsuda T, Tanaka H, Hanumadass M, Gayle R, Yuasa H, Abcarian H, Matsuda H, Reyes H
Burn Center, Cook County Hospital, Chicago, IL 60612.
J Burn Care Rehabil. 1992 Sep-Oct;13(5):560-6. doi: 10.1097/00004630-199209000-00009.
The effects of vitamin C treatment (14 mg/kg/hr) on burn injury were evaluated in the hind paws of 12 mongrel dogs. A lymph duct above one hind paw of each dog was cannulated. Hourly lymph flow rates (QL) and plasma and lymph total protein concentrations were measured before the burn injury and for 6 hours after the burn injury. Data from 24 paws were divided into four groups: nonburn without treatment, nonburn with treatment, burn without treatment, and burn with treatment. The nonburn groups showed no significant differences in QL or in total protein flux. In the burn groups the postburn hourly QL increased by sevenfold in the nontreatment group and only by threefold in the treatment group, whereas the postburn hourly total protein flux increased by fifteenfold and fivefold, respectively. We conclude that administration of high-dose vitamin C reduces early postburn microvascular leakage of fluid and protein.
在12只杂种犬的后爪上评估了维生素C治疗（14毫克/千克/小时）对烧伤的影响。对每只犬一只后爪上方的淋巴管进行插管。在烧伤前以及烧伤后6小时测量每小时的淋巴流速（QL）以及血浆和淋巴中的总蛋白浓度。来自24只爪子的数据被分为四组：未烧伤未治疗组、未烧伤治疗组、烧伤未治疗组和烧伤治疗组。未烧伤组在QL或总蛋白通量方面没有显著差异。在烧伤组中，未治疗组烧伤后每小时的QL增加了7倍，而治疗组仅增加了3倍，而烧伤后每小时的总蛋白通量分别增加了15倍和5倍。我们得出结论，高剂量维生素C的给药可减少烧伤后早期微血管的液体和蛋白质渗漏。
