Matsuda T, Tanaka H, Yuasa H, Forrest R, Matsuda H, Hanumadass M, Reyes H
Burn Center, Cook County Hospital, Chicago, IL 60612.
J Burn Care Rehabil. 1993 Nov-Dec;14(6):624-9. doi: 10.1097/00004630-199311000-00007.
The effects of vitamin C treatment (14 mg/kg/hr) on postburn lipid peroxidation were evaluated in 12 dogs. A lymph duct above the ankle was cannulated bilaterally. Hourly lymph flow rates, plasma and lymph total protein concentrations, and plasma and lymph malondialdehyde concentrations were measured before the burn injury and for 24 hours after the burn injury. Four groups were employed: nonburn without treatment, nonburn with vitamin C treatment, burn without treatment, and burn with vitamin C treatment. The nonburn groups showed no significant differences in lymph flow rates, total protein flux, or lymph malondialdehyde level. In the burn groups the postburn hourly lymph flow rate increased by 850% without treatment and by 500% with vitamin C treatment, whereas the postburn hourly total protein flux increased by fiftyfold and twentyfold, respectively. There was a significant reduction in the postburn lymph malondialdehyde level in the group treated with vitamin C as compared with the nontreatment group. We conclude that high-dose vitamin C administration diminishes early postburn lipid peroxidation and reduces microvascular leakage of fluid and protein.
在12只犬中评估了维生素C治疗（14毫克/千克/小时）对烧伤后脂质过氧化的影响。双侧踝关节上方的淋巴管被插管。在烧伤前以及烧伤后24小时测量每小时的淋巴流速、血浆和淋巴总蛋白浓度以及血浆和淋巴丙二醛浓度。分为四组：未烧伤未治疗组、未烧伤维生素C治疗组、烧伤未治疗组和烧伤维生素C治疗组。未烧伤组在淋巴流速、总蛋白通量或淋巴丙二醛水平上无显著差异。在烧伤组中，未治疗时烧伤后每小时淋巴流速增加了850%，维生素C治疗时增加了500%，而烧伤后每小时总蛋白通量分别增加了五十倍和二十倍。与未治疗组相比，维生素C治疗组烧伤后淋巴丙二醛水平显著降低。我们得出结论，大剂量给予维生素C可减少烧伤后早期的脂质过氧化，并减少液体和蛋白质的微血管渗漏。
