Salkin I F, Cooper C R, Bartges J W, Kemna M E, Rinaldi M G
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
J Clin Microbiol. 1992 Nov;30(11):2797-800. doi: 10.1128/jcm.30.11.2797-2800.1992.
Scedosporium inflatum Malloch et Salkin was found to cause osteomyelitis in a 6-year-old spayed female beagle. The previously healthy dog suddenly developed right-forelimb lameness. Bony changes consisting of proliferation with some lysis were noted on radiographic examinations. Microscopic observations of stained sections of tissue obtained by biopsy of the distal humerus revealed the presence of septate branching hyphae. Cultures inoculated with tissue from a later biopsy yielded a mold subsequently identified as S. inflatum. Tissue sections stained with specific Scedosporium fluorescent-antibody conjugate were positive, further substantiating the diagnosis. Although the dog was treated with oral itraconazole, no improvement in the animal's condition was noted, and it was euthanized. Autopsy revealed dissemination of the etiologic agent to the lungs.
发现膨胀瓶霉（Scedosporium inflatum Malloch et Salkin）可导致一只6岁已绝育雌性比格犬发生骨髓炎。这只此前健康的犬突然出现右前肢跛行。X线检查发现有包括骨质增生伴部分骨质溶解的骨改变。对取自肱骨远端活检组织的染色切片进行显微镜观察，发现有分隔的分支菌丝。用后来活检组织接种的培养物长出一种霉菌，随后鉴定为膨胀瓶霉。用特异性瓶霉荧光抗体结合物染色的组织切片呈阳性，进一步证实了诊断。尽管给这只犬口服伊曲康唑进行治疗，但未观察到动物病情有改善，遂对其实施安乐死。尸检发现病原体扩散至肺部。
