Nechaev Sergei, Severinov Konstantin
Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093-0634, USA.
Annu Rev Microbiol. 2003;57:301-22. doi: 10.1146/annurev.micro.57.030502.090942.
Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.
噬菌体已经进化出一系列令人印象深刻的巧妙机制，来修饰细菌宿主的RNA聚合酶，使其满足病毒的需求。在这篇综述中，我们总结了目前关于双链DNA噬菌体诱导的两种宿主RNA聚合酶修饰的知识：共价修饰和通过RNA聚合酶结合蛋白进行的修饰。我们在细菌RNA聚合酶的结构-功能模型和病毒生物学的框架内解读生化和遗传数据。
