Swirsky-Sacchetti T, Field H L, Mitchell D R, Seward J, Lublin F D, Knobler R L, Gonzalez C F
Jefferson Medical College, Philadelphia, PA 19107.
J Clin Psychol. 1992 Nov;48(6):779-86. doi: 10.1002/1097-4679(199211)48:6<779::aid-jclp2270480612>3.0.co;2-b.
Fifty-six patients diagnosed with definite multiple sclerosis (MS) according to Poser criteria were administered the Mini-Mental State Examination (MMSE) and a comprehensive battery of neuropsychological tests. Extent of cerebral lesion involvement was determined by quantitative magnetic resonance imaging (MRI) ratings. The MMSE correlated with overall levels of physical disability, but did not correlate with total lesion area on MRI. Sensitivity of the MMSE to the subcortical dementia of MS was low (28%) when performance on the neuropsychological testing battery was used as the criterion. Impairment on tests of memory, speed of information processing, abstract reasoning, naming/verbal fluency, as well as visuoperceptual organization, were correlated highly with total lesion area on MRI. The low sensitivity of the MMSE to cognitive impairment in MS is discussed in terms of its item composition and the characteristic pattern of deficits found in MS.
根据波泽标准确诊为明确多发性硬化症（MS）的56例患者接受了简易精神状态检查表（MMSE）和一系列全面的神经心理学测试。通过定量磁共振成像（MRI）评分确定脑损伤的累及程度。MMSE与身体残疾的总体水平相关，但与MRI上的总病变面积无关。以神经心理学测试组合的表现为标准时，MMSE对MS皮质下痴呆的敏感性较低（28%）。记忆测试、信息处理速度、抽象推理、命名/语言流畅性以及视觉感知组织方面的损伤与MRI上的总病变面积高度相关。从MMSE的项目构成以及MS中发现的缺陷特征模式方面讨论了MMSE对MS认知障碍敏感性较低的问题。
