Cabrera DeBuc Delia, Gaca-Wysocka Magdalena, Grzybowski Andrzej, Kanclerz Piotr
Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Poznań City Hospital, 61-285 Poznań, Poland.
J Clin Med. 2019 Jul 9;8(7):996. doi: 10.3390/jcm8070996.
This review will highlight recent insights into measuring retinal structure in Alzheimer's disease (AD). A growing body of evidence indicates that disturbances in retinal blood flow and structure are related to cognitive function, which can severely impair vision. Optical coherence tomography (OCT) is an optical imaging technology that may allow researchers and physicians to gain deeper insights into retinal morphology and clarify the impact of AD on retinal health and function. Direct and noninvasive measurement of retinal morphology using OCT has provided useful diagnostic and therapeutic indications in several central nervous system (CNS) diseases, including AD, multiple sclerosis, and Parkinson disease. Despite several limitations, morphology assessment in the retinal layers is a significant advancement in the understanding of ocular diseases. Nevertheless, additional studies are required to validate the use of OCT in AD and its complications in the eye.
本综述将重点介绍阿尔茨海默病（AD）视网膜结构测量方面的最新见解。越来越多的证据表明，视网膜血流和结构紊乱与认知功能有关，而认知功能会严重损害视力。光学相干断层扫描（OCT）是一种光学成像技术，它可能使研究人员和医生更深入地了解视网膜形态，并阐明AD对视网膜健康和功能的影响。使用OCT直接且无创地测量视网膜形态，已在包括AD、多发性硬化症和帕金森病在内的几种中枢神经系统（CNS）疾病中提供了有用的诊断和治疗指征。尽管存在一些局限性，但视网膜层形态学评估在眼部疾病的认识方面是一项重大进展。然而，还需要更多研究来验证OCT在AD及其眼部并发症中的应用。
